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[Resistance to the inhibiting action of dexamethasone and the risk of postoperative complications in colonic and rectal cancer].
Vopr Onkol. 1981; 27(4):48-52.VO

Abstract

Dexamethasone-induced decrease in 11-hydroxycorticosteroid level was studied in 55 patients with primary tumors of the colon and rectum several days before operation. All lethal outcomes and most postoperative complications were registered in cases resistant to dexamethasone. The elevated threshold of hypothalamic sensitivity to inhibition by glucocorticoids is considered to be due to the influence of age, tumor process and long-term emotional stress during preoperative period, all these factors affecting the adaptive potential.

Authors

Ostroumova MN
No affiliation info available
Simonov NN
No affiliation info available

MeSH

Adaptation, PhysiologicalAdultAgedColonic NeoplasmsDexamethasoneDrug ResistanceFemaleHumansMaleMiddle AgedPostoperative ComplicationsRectal NeoplasmsRisk

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

7233875

Citation

Ostroumova, M N., and N N. Simonov. "[Resistance to the Inhibiting Action of Dexamethasone and the Risk of Postoperative Complications in Colonic and Rectal Cancer]." Voprosy Onkologii, vol. 27, no. 4, 1981, pp. 48-52.
Ostroumova MN, Simonov NN. [Resistance to the inhibiting action of dexamethasone and the risk of postoperative complications in colonic and rectal cancer]. Vopr Onkol. 1981;27(4):48-52.
Ostroumova, M. N., & Simonov, N. N. (1981). [Resistance to the inhibiting action of dexamethasone and the risk of postoperative complications in colonic and rectal cancer]. Voprosy Onkologii, 27(4), 48-52.
Ostroumova MN, Simonov NN. [Resistance to the Inhibiting Action of Dexamethasone and the Risk of Postoperative Complications in Colonic and Rectal Cancer]. Vopr Onkol. 1981;27(4):48-52. PubMed PMID: 7233875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Resistance to the inhibiting action of dexamethasone and the risk of postoperative complications in colonic and rectal cancer]. AU - Ostroumova,M N, AU - Simonov,N N, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 48 EP - 52 JF - Voprosy onkologii JO - Vopr Onkol VL - 27 IS - 4 N2 - Dexamethasone-induced decrease in 11-hydroxycorticosteroid level was studied in 55 patients with primary tumors of the colon and rectum several days before operation. All lethal outcomes and most postoperative complications were registered in cases resistant to dexamethasone. The elevated threshold of hypothalamic sensitivity to inhibition by glucocorticoids is considered to be due to the influence of age, tumor process and long-term emotional stress during preoperative period, all these factors affecting the adaptive potential. SN - 0507-3758 UR - https://www.unboundmedicine.com/medline/citation/7233875/[Resistance_to_the_inhibiting_action_of_dexamethasone_and_the_risk_of_postoperative_complications_in_colonic_and_rectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/6169 DB - PRIME DP - Unbound Medicine ER -