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Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease.
Pharmatherapeutica 1981; 2(8):528-31P

Abstract

A previous study showed that regional cerebral blood flow, measured following intra-arterial injection of 133Xenon, increased by at least 15% in one-third of all areas investigated in 25 patients with different types of dementia after a 2-weeks' period of intravenous treatment with 600 mg pentoxifylline per day. In the present studies, 10 patients were treated orally with 400 mg pentoxifylline 3-times daily for 4 weeks and 10 untreated patients served as controls. Regional cerebral blood flow was measured over both hemispheres using a new non-invasive technique by inhalation of 133Xenon gas. Bihemispheric cerebral blood flow increased by 15.9% in the pentoxifylline group and by 1.7% in the controls. Hypoemic areas, in particular, showed a distinctly higher increase (+20.1%) in blood flow after pentoxifylline compared to controls (+0.7%), and these hypoemic areas were apparently more influenced than hyperemic or normoemic regions. These findings were confirmed by a second controlled series. These data suggest an improvement of cerebral blood flow by pentoxifylline in a certain number of brain tissue areas if the drug is given over periods of at least 2 weeks in patients with cerebrovascular disease and other types of dementia.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7255509

Citation

Hartmann, A. "Effect of Pentoxifylline On Regional Cerebral Blood Flow in Patients With Cerebrovascular Disease." Pharmatherapeutica, vol. 2, no. 8, 1981, pp. 528-31.
Hartmann A. Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease. Pharmatherapeutica. 1981;2(8):528-31.
Hartmann, A. (1981). Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease. Pharmatherapeutica, 2(8), pp. 528-31.
Hartmann A. Effect of Pentoxifylline On Regional Cerebral Blood Flow in Patients With Cerebrovascular Disease. Pharmatherapeutica. 1981;2(8):528-31. PubMed PMID: 7255509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease. A1 - Hartmann,A, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 528 EP - 31 JF - Pharmatherapeutica JO - Pharmatherapeutica VL - 2 IS - 8 N2 - A previous study showed that regional cerebral blood flow, measured following intra-arterial injection of 133Xenon, increased by at least 15% in one-third of all areas investigated in 25 patients with different types of dementia after a 2-weeks' period of intravenous treatment with 600 mg pentoxifylline per day. In the present studies, 10 patients were treated orally with 400 mg pentoxifylline 3-times daily for 4 weeks and 10 untreated patients served as controls. Regional cerebral blood flow was measured over both hemispheres using a new non-invasive technique by inhalation of 133Xenon gas. Bihemispheric cerebral blood flow increased by 15.9% in the pentoxifylline group and by 1.7% in the controls. Hypoemic areas, in particular, showed a distinctly higher increase (+20.1%) in blood flow after pentoxifylline compared to controls (+0.7%), and these hypoemic areas were apparently more influenced than hyperemic or normoemic regions. These findings were confirmed by a second controlled series. These data suggest an improvement of cerebral blood flow by pentoxifylline in a certain number of brain tissue areas if the drug is given over periods of at least 2 weeks in patients with cerebrovascular disease and other types of dementia. SN - 0308-051X UR - https://www.unboundmedicine.com/medline/citation/7255509/Effect_of_pentoxifylline_on_regional_cerebral_blood_flow_in_patients_with_cerebrovascular_disease_ DB - PRIME DP - Unbound Medicine ER -