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The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed.
Pharmazie. 1981 Apr; 36(4):270-3.P

Abstract

With the help of a factorial design of experiments, the optimum conditions for preparing aminophenazone granules in a fluidized bed were established by which high quality tablets were obtained with a minimum energy expenditure. Granules with given technological properties could be prepared by controlling the regime of the granulation process. By varying the experimental conditions, a reproducible correlation was found between the parameters of optimization (mean granule diameter and work of compression) and the factors controlling the granulation process (pressure of compressed air, velocity and temperature of fluidizing air and binder concentration). The effect of the granule quality on tablet physical properties was discussed. Recommendations were given for the exploitation of fluidized bed units in the practice of granulation and tableting.

Authors

Gorodnichev VI
No affiliation info available
El-Banna HM
No affiliation info available
Andreev BV
No affiliation info available

MeSH

AminopyrineChemistry, PharmaceuticalDrug CompoundingHardnessMathematicsPowdersTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7255528

Citation

Gorodnichev, V I., et al. "The Construction and Uses of Factorial Designs in the Preparation of Solid Dosage Forms. Part 2: Granulation in a Fluidized Bed." Die Pharmazie, vol. 36, no. 4, 1981, pp. 270-3.
Gorodnichev VI, El-Banna HM, Andreev BV. The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed. Pharmazie. 1981;36(4):270-3.
Gorodnichev, V. I., El-Banna, H. M., & Andreev, B. V. (1981). The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed. Die Pharmazie, 36(4), 270-3.
Gorodnichev VI, El-Banna HM, Andreev BV. The Construction and Uses of Factorial Designs in the Preparation of Solid Dosage Forms. Part 2: Granulation in a Fluidized Bed. Pharmazie. 1981;36(4):270-3. PubMed PMID: 7255528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The construction and uses of factorial designs in the preparation of solid dosage forms. Part 2: Granulation in a fluidized bed. AU - Gorodnichev,V I, AU - El-Banna,H M, AU - Andreev,B V, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 270 EP - 3 JF - Die Pharmazie JO - Pharmazie VL - 36 IS - 4 N2 - With the help of a factorial design of experiments, the optimum conditions for preparing aminophenazone granules in a fluidized bed were established by which high quality tablets were obtained with a minimum energy expenditure. Granules with given technological properties could be prepared by controlling the regime of the granulation process. By varying the experimental conditions, a reproducible correlation was found between the parameters of optimization (mean granule diameter and work of compression) and the factors controlling the granulation process (pressure of compressed air, velocity and temperature of fluidizing air and binder concentration). The effect of the granule quality on tablet physical properties was discussed. Recommendations were given for the exploitation of fluidized bed units in the practice of granulation and tableting. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/7255528/The_construction_and_uses_of_factorial_designs_in_the_preparation_of_solid_dosage_forms__Part_2:_Granulation_in_a_fluidized_bed_ DB - PRIME DP - Unbound Medicine ER -