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Failure of the hydrogen breath test to detect pulmonary sugar malabsorption.
Arch Dis Child. 1981 May; 56(5):368-72.AD

Abstract

Five patients with sucrase-isomaltase deficiency, and one patient with primary glucose-galactose malabsorption had no increases in breath hydrogen excretion after oral sucrose or glucose. Anaerobic incubation with sugars of stool suspensions from 5 patients with primary sugar malabsorption produced by trace of hydrogen (17 microliter) in only one, while those from 13 or 14 controls produced a mean hydrogen volume of 640 microliter under similar conditions. Altered bacterial metabolism is a probable explanation. Breath hydrogen excretion did increase appreciably in 2 of these patients after oral lactulose showing that hydrogen excretion may vary according to the substrate. Therefore, observation of breath hydrogen excretion after lactulose is not recommended as a means of predicting false-negative breath tests with other sugars. The hydrogen breath test is not a reliable mean of diagnosing primary sugar malabsorption in children.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7259258

Citation

Gardiner, A J., et al. "Failure of the Hydrogen Breath Test to Detect Pulmonary Sugar Malabsorption." Archives of Disease in Childhood, vol. 56, no. 5, 1981, pp. 368-72.
Gardiner AJ, Tarlow MJ, Symonds J, et al. Failure of the hydrogen breath test to detect pulmonary sugar malabsorption. Arch Dis Child. 1981;56(5):368-72.
Gardiner, A. J., Tarlow, M. J., Symonds, J., Hutchison, J. G., & Sutherland, I. T. (1981). Failure of the hydrogen breath test to detect pulmonary sugar malabsorption. Archives of Disease in Childhood, 56(5), 368-72.
Gardiner AJ, et al. Failure of the Hydrogen Breath Test to Detect Pulmonary Sugar Malabsorption. Arch Dis Child. 1981;56(5):368-72. PubMed PMID: 7259258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Failure of the hydrogen breath test to detect pulmonary sugar malabsorption. AU - Gardiner,A J, AU - Tarlow,M J, AU - Symonds,J, AU - Hutchison,J G, AU - Sutherland,I T, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 368 EP - 72 JF - Archives of disease in childhood JO - Arch Dis Child VL - 56 IS - 5 N2 - Five patients with sucrase-isomaltase deficiency, and one patient with primary glucose-galactose malabsorption had no increases in breath hydrogen excretion after oral sucrose or glucose. Anaerobic incubation with sugars of stool suspensions from 5 patients with primary sugar malabsorption produced by trace of hydrogen (17 microliter) in only one, while those from 13 or 14 controls produced a mean hydrogen volume of 640 microliter under similar conditions. Altered bacterial metabolism is a probable explanation. Breath hydrogen excretion did increase appreciably in 2 of these patients after oral lactulose showing that hydrogen excretion may vary according to the substrate. Therefore, observation of breath hydrogen excretion after lactulose is not recommended as a means of predicting false-negative breath tests with other sugars. The hydrogen breath test is not a reliable mean of diagnosing primary sugar malabsorption in children. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/7259258/Failure_of_the_hydrogen_breath_test_to_detect_pulmonary_sugar_malabsorption_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7259258/ DB - PRIME DP - Unbound Medicine ER -