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Thyroid hormones in acute myocardial infarction.
Clin Endocrinol (Oxf). 1981 Apr; 14(4):367-74.CE

Abstract

Thyroid hormones were serially measured over a 2-week period in thirty-four consecutive patients with acute myocardial infarction (AMI). A transient increase in plasma rT3 and a decrease in plasma T3 was found, with the maximum changes occurring on the third day after the onset of AMI. The changes in plasma rT3 and T3 were greater in the seventeen patients with a complicated AMI (mean peak SGOT 145 mu/l) than in the seventeen patients with an uncomplicated AMI (mean peak SGOT 79 mu/l). A correlation was found between infarct size (as estimated by the peak SGOT value) and the following indices: delta r T3, delta T3, highest rT3/t3 and highest rT3/T4 ratios. A transient increase in plasma TSH (peak on days 4 and 5) and in plasma T4 and FT4 index (peak on days 6 and 7) was also observed, whereas T3 resin uptake (T3U) decreased. These findings suggest that the following sequence of events occurs in thyroid hormone metabolism during AMI: (1) inhibition of the 5'-deiodination of T4, resulting in increased plasma rT3 and decreased plasma T3 values, and in a lower metabolic clearance of T4. (2) Increased secretion of TSH (provoked by the lower T3 levels) resulting in increased thyroidal secretion of T4 and T3, which is then switched off by the negative feedback of thyroid hormones on the pituitary.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7261419

Citation

Wiersinga, W M., et al. "Thyroid Hormones in Acute Myocardial Infarction." Clinical Endocrinology, vol. 14, no. 4, 1981, pp. 367-74.
Wiersinga WM, Lie KI, Touber JL. Thyroid hormones in acute myocardial infarction. Clin Endocrinol (Oxf). 1981;14(4):367-74.
Wiersinga, W. M., Lie, K. I., & Touber, J. L. (1981). Thyroid hormones in acute myocardial infarction. Clinical Endocrinology, 14(4), 367-74.
Wiersinga WM, Lie KI, Touber JL. Thyroid Hormones in Acute Myocardial Infarction. Clin Endocrinol (Oxf). 1981;14(4):367-74. PubMed PMID: 7261419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid hormones in acute myocardial infarction. AU - Wiersinga,W M, AU - Lie,K I, AU - Touber,J L, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 367 EP - 74 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 14 IS - 4 N2 - Thyroid hormones were serially measured over a 2-week period in thirty-four consecutive patients with acute myocardial infarction (AMI). A transient increase in plasma rT3 and a decrease in plasma T3 was found, with the maximum changes occurring on the third day after the onset of AMI. The changes in plasma rT3 and T3 were greater in the seventeen patients with a complicated AMI (mean peak SGOT 145 mu/l) than in the seventeen patients with an uncomplicated AMI (mean peak SGOT 79 mu/l). A correlation was found between infarct size (as estimated by the peak SGOT value) and the following indices: delta r T3, delta T3, highest rT3/t3 and highest rT3/T4 ratios. A transient increase in plasma TSH (peak on days 4 and 5) and in plasma T4 and FT4 index (peak on days 6 and 7) was also observed, whereas T3 resin uptake (T3U) decreased. These findings suggest that the following sequence of events occurs in thyroid hormone metabolism during AMI: (1) inhibition of the 5'-deiodination of T4, resulting in increased plasma rT3 and decreased plasma T3 values, and in a lower metabolic clearance of T4. (2) Increased secretion of TSH (provoked by the lower T3 levels) resulting in increased thyroidal secretion of T4 and T3, which is then switched off by the negative feedback of thyroid hormones on the pituitary. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/7261419/Thyroid_hormones_in_acute_myocardial_infarction_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1981&volume=14&issue=4&spage=367 DB - PRIME DP - Unbound Medicine ER -