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Effects of hypothermia on ionic movement in the guinea pig cochlea.
Hear Res 1981; 4(3-4):265-78HR

Abstract

Anesthetized and immobilized guinea pigs were subjected to hypothermia. During cooling, the cochlear microphonics and endocochlear potential decreased and K+ concentrations in both endolymph and perilymph were not significantly affected. The rate constant for K+ turnover to endolymph was determined by uptake of 43K into the endolymph when the perilymphatic space was perfused with artificial perilymph containing 43K. The rate constant for K+ decreased significantly in hypothermic guinea pigs when compared with that in normal guinea pigs. The K+ conductance of the endolymph-perilymph barrier, estimated from the rate constant, showed a marked decrease in hypothermic guinea pigs and was comparable with the K+ conductance, calculated from the rate of change of the endolymph K+ concentrations relative to the K+ electrochemical potential difference, recorded during permanent anoxia. These results suggest that hypothermia not only suppresses the active K+ transport system but also decreases the K+ permeability of the endolymph-perilymph barrier.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7263514

Citation

Konishi, T, et al. "Effects of Hypothermia On Ionic Movement in the Guinea Pig Cochlea." Hearing Research, vol. 4, no. 3-4, 1981, pp. 265-78.
Konishi T, Salt AN, Hamrick PE. Effects of hypothermia on ionic movement in the guinea pig cochlea. Hear Res. 1981;4(3-4):265-78.
Konishi, T., Salt, A. N., & Hamrick, P. E. (1981). Effects of hypothermia on ionic movement in the guinea pig cochlea. Hearing Research, 4(3-4), pp. 265-78.
Konishi T, Salt AN, Hamrick PE. Effects of Hypothermia On Ionic Movement in the Guinea Pig Cochlea. Hear Res. 1981;4(3-4):265-78. PubMed PMID: 7263514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hypothermia on ionic movement in the guinea pig cochlea. AU - Konishi,T, AU - Salt,A N, AU - Hamrick,P E, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 265 EP - 78 JF - Hearing research JO - Hear. Res. VL - 4 IS - 3-4 N2 - Anesthetized and immobilized guinea pigs were subjected to hypothermia. During cooling, the cochlear microphonics and endocochlear potential decreased and K+ concentrations in both endolymph and perilymph were not significantly affected. The rate constant for K+ turnover to endolymph was determined by uptake of 43K into the endolymph when the perilymphatic space was perfused with artificial perilymph containing 43K. The rate constant for K+ decreased significantly in hypothermic guinea pigs when compared with that in normal guinea pigs. The K+ conductance of the endolymph-perilymph barrier, estimated from the rate constant, showed a marked decrease in hypothermic guinea pigs and was comparable with the K+ conductance, calculated from the rate of change of the endolymph K+ concentrations relative to the K+ electrochemical potential difference, recorded during permanent anoxia. These results suggest that hypothermia not only suppresses the active K+ transport system but also decreases the K+ permeability of the endolymph-perilymph barrier. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/7263514/Effects_of_hypothermia_on_ionic_movement_in_the_guinea_pig_cochlea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(81)90011-3 DB - PRIME DP - Unbound Medicine ER -