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High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations.
J Chromatogr 1981; 212(3):331-8JC

Abstract

A high-performance liquid chromatographic method is described which allows the simultaneous estimation of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid. The method offers advantages over existing chromatographic procedures in that pilocarpine and the degradation products are eluted within 15 min making the procedure suitable for routine quality control. Pilocarpine eye-drop preparations available on the Australian market were determined to contain between 0.4 and 1.9% isopilocarpine and between 2.2 and 6.3% total pilocarpic acids. These findings are comparable to those reported by Weber in a survey of pilocarpine containing products available in the U.S.A.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7263802

Citation

Kennedy, J M., and P E. McNamara. "High-performance Liquid Chromatographic Analysis of Pilocarpine Hydrochloride, Isopilocarpine, Pilocarpic Acid and Isopilocarpic Acid in Eye-drop Preparations." Journal of Chromatography, vol. 212, no. 3, 1981, pp. 331-8.
Kennedy JM, McNamara PE. High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations. J Chromatogr. 1981;212(3):331-8.
Kennedy, J. M., & McNamara, P. E. (1981). High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations. Journal of Chromatography, 212(3), pp. 331-8.
Kennedy JM, McNamara PE. High-performance Liquid Chromatographic Analysis of Pilocarpine Hydrochloride, Isopilocarpine, Pilocarpic Acid and Isopilocarpic Acid in Eye-drop Preparations. J Chromatogr. 1981 Aug 7;212(3):331-8. PubMed PMID: 7263802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations. AU - Kennedy,J M, AU - McNamara,P E, PY - 1981/8/7/pubmed PY - 1981/8/7/medline PY - 1981/8/7/entrez SP - 331 EP - 8 JF - Journal of chromatography JO - J. Chromatogr. VL - 212 IS - 3 N2 - A high-performance liquid chromatographic method is described which allows the simultaneous estimation of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid. The method offers advantages over existing chromatographic procedures in that pilocarpine and the degradation products are eluted within 15 min making the procedure suitable for routine quality control. Pilocarpine eye-drop preparations available on the Australian market were determined to contain between 0.4 and 1.9% isopilocarpine and between 2.2 and 6.3% total pilocarpic acids. These findings are comparable to those reported by Weber in a survey of pilocarpine containing products available in the U.S.A. UR - https://www.unboundmedicine.com/medline/citation/7263802/High_performance_liquid_chromatographic_analysis_of_pilocarpine_hydrochloride_isopilocarpine_pilocarpic_acid_and_isopilocarpic_acid_in_eye_drop_preparations_ DB - PRIME DP - Unbound Medicine ER -