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Assessment of the methods available for the determination of carbon monoxide in blood.
J Anal Toxicol. 1981 May-Jun; 5(3):122-5.JA

Abstract

Experimental evaluation of methods for assessing the carboxyhemoglobin (COHb) content in blood using gas chromatography, UV-visible spectrophotometry (three methods), and magnetic circular dichroism (MCD) has been made. From the point of view of measurements where the COHb content is low (less than 15%), elevated simply by the smoking population, the spectrophotometric method by Rodkey, et al. (7) emerges as the most satisfactory. MCD analysis, however, is potentially considerably simpler, not requiring chemical pretreatment of the blood, and provided that analysis time can be improved, is likely to replace the spectrophotometric method as the method of choice.

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Authors

Wigfield DC
No affiliation info available
Hollebone BR
No affiliation info available
MacKeen JE
No affiliation info available
Selwin JC
No affiliation info available

MeSH

Carbon MonoxideCarboxyhemoglobinChromatography, GasCircular DichroismHumansSpectrophotometry

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7265924

Citation

Wigfield, D C., et al. "Assessment of the Methods Available for the Determination of Carbon Monoxide in Blood." Journal of Analytical Toxicology, vol. 5, no. 3, 1981, pp. 122-5.
Wigfield DC, Hollebone BR, MacKeen JE, et al. Assessment of the methods available for the determination of carbon monoxide in blood. J Anal Toxicol. 1981;5(3):122-5.
Wigfield, D. C., Hollebone, B. R., MacKeen, J. E., & Selwin, J. C. (1981). Assessment of the methods available for the determination of carbon monoxide in blood. Journal of Analytical Toxicology, 5(3), 122-5.
Wigfield DC, et al. Assessment of the Methods Available for the Determination of Carbon Monoxide in Blood. J Anal Toxicol. 1981 May-Jun;5(3):122-5. PubMed PMID: 7265924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the methods available for the determination of carbon monoxide in blood. AU - Wigfield,D C, AU - Hollebone,B R, AU - MacKeen,J E, AU - Selwin,J C, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 122 EP - 5 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 5 IS - 3 N2 - Experimental evaluation of methods for assessing the carboxyhemoglobin (COHb) content in blood using gas chromatography, UV-visible spectrophotometry (three methods), and magnetic circular dichroism (MCD) has been made. From the point of view of measurements where the COHb content is low (less than 15%), elevated simply by the smoking population, the spectrophotometric method by Rodkey, et al. (7) emerges as the most satisfactory. MCD analysis, however, is potentially considerably simpler, not requiring chemical pretreatment of the blood, and provided that analysis time can be improved, is likely to replace the spectrophotometric method as the method of choice. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/7265924/Assessment_of_the_methods_available_for_the_determination_of_carbon_monoxide_in_blood_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/5.3.122 DB - PRIME DP - Unbound Medicine ER -