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Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations.
Am J Clin Nutr. 1981 Aug; 34(8):1600-10.AJ

Abstract

The diagnostic usefulness in iron deficiency anemia of serum ferritin, red cell protoporphyrin (Epp), mean corpuscular volume, mean corpuscular hemoglobin (MCH), and transferrin saturation measurements has been studied in a population of 294 children aged 1 to 6 yr. Of the children studied 19% had hemoglobin below 11 g/dl. Iron deficiency, diagnosed by at least two abnormal independent laboratory parameters, was the cause of anemia in all except two cases. The Pearson correlation coefficient for hemoglobin was highest with MCH, followed in decreasing order of magnitude by MCV, Epp, transferrin saturation, and finally by ferritin. Sensitivity and specificity were highest for MCH and lowest for ferritin. Of anemic, iron deficient individuals 97 to 100% could be identified by low MCH, 88 to 100% by transferrin saturation, 66 to 83% by ferritin, and 61 to 74% by Epp. In contrast, only 0 to 6% of normal, nonanemic individuals had low MCH, 0 to 4% had high Epp, but 21 to 39% had low transferrin saturation and 25 to 39% had low ferritin. Although reduced serum ferritin in anemic individuals is good evidence of iron deficiency, a significant proportion of anemic iron-deficient patients is missed by this procedure rendering it less useful than other, less expensive laboratory methods.

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Authors

Hershko C
No affiliation info available
Bar-Or D
No affiliation info available
Gaziel Y
No affiliation info available
Naparstek E
No affiliation info available
Konijn AM
No affiliation info available
Grossowicz N
No affiliation info available
Kaufman N
No affiliation info available
Izak G
No affiliation info available

MeSH

Age FactorsAnemia, HypochromicChildChild, PreschoolErythrocyte IndicesErythrocytesFemaleFerritinsHemoglobinsHumansInfantIsraelMalePorphyrinsProtoporphyrinsRural PopulationTransferrin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7270484

Citation

Hershko, C, et al. "Diagnosis of Iron Deficiency Anemia in a Rural Population of Children. Relative Usefulness of Serum Ferritin, Red Cell Protoporphyrin, Red Cell Indices, and Transferrin Saturation Determinations." The American Journal of Clinical Nutrition, vol. 34, no. 8, 1981, pp. 1600-10.
Hershko C, Bar-Or D, Gaziel Y, et al. Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations. Am J Clin Nutr. 1981;34(8):1600-10.
Hershko, C., Bar-Or, D., Gaziel, Y., Naparstek, E., Konijn, A. M., Grossowicz, N., Kaufman, N., & Izak, G. (1981). Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations. The American Journal of Clinical Nutrition, 34(8), 1600-10.
Hershko C, et al. Diagnosis of Iron Deficiency Anemia in a Rural Population of Children. Relative Usefulness of Serum Ferritin, Red Cell Protoporphyrin, Red Cell Indices, and Transferrin Saturation Determinations. Am J Clin Nutr. 1981;34(8):1600-10. PubMed PMID: 7270484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations. AU - Hershko,C, AU - Bar-Or,D, AU - Gaziel,Y, AU - Naparstek,E, AU - Konijn,A M, AU - Grossowicz,N, AU - Kaufman,N, AU - Izak,G, PY - 1981/8/1/pubmed PY - 1981/8/1/medline PY - 1981/8/1/entrez SP - 1600 EP - 10 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 34 IS - 8 N2 - The diagnostic usefulness in iron deficiency anemia of serum ferritin, red cell protoporphyrin (Epp), mean corpuscular volume, mean corpuscular hemoglobin (MCH), and transferrin saturation measurements has been studied in a population of 294 children aged 1 to 6 yr. Of the children studied 19% had hemoglobin below 11 g/dl. Iron deficiency, diagnosed by at least two abnormal independent laboratory parameters, was the cause of anemia in all except two cases. The Pearson correlation coefficient for hemoglobin was highest with MCH, followed in decreasing order of magnitude by MCV, Epp, transferrin saturation, and finally by ferritin. Sensitivity and specificity were highest for MCH and lowest for ferritin. Of anemic, iron deficient individuals 97 to 100% could be identified by low MCH, 88 to 100% by transferrin saturation, 66 to 83% by ferritin, and 61 to 74% by Epp. In contrast, only 0 to 6% of normal, nonanemic individuals had low MCH, 0 to 4% had high Epp, but 21 to 39% had low transferrin saturation and 25 to 39% had low ferritin. Although reduced serum ferritin in anemic individuals is good evidence of iron deficiency, a significant proportion of anemic iron-deficient patients is missed by this procedure rendering it less useful than other, less expensive laboratory methods. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/7270484/Diagnosis_of_iron_deficiency_anemia_in_a_rural_population_of_children__Relative_usefulness_of_serum_ferritin_red_cell_protoporphyrin_red_cell_indices_and_transferrin_saturation_determinations_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/34.8.1600 DB - PRIME DP - Unbound Medicine ER -