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Partial prevention of glucocorticoid-induced muscle atrophy by endurance training.
Am J Physiol. 1981 Sep; 241(3):E226-32.AJ

Abstract

Male rats were either sham-operated (N) or castrated (C) at 65 days of age. They were further subdivided into sedentary or exercise groups that were trained by treadmill running 5 days/wk for 12 wk. During the last 10 days of training, the animals received daily subcutaneous injections of cortisone acetate (CA) (100 mg/kg) or 1% carboxymethylcellulose. Body weight decreased approximately 25% in all groups that received CA. The fast-twitch plantaris and gastrocnemius muscle weights were approximately 35% lower in CA-treated versus cortisone-free N and C sedentary animals. Exercise prevented from one-fourth to one-half of the muscle weight loss in N and C runners when compared to their respective pair weight controls. Muscle weights of the CA-treated freely eating N controls were significantly less than that of N runners that received CA. In plantaris muscles of both N and C animals that received CA, total protein concentration and citrate synthase activity, a mitochondrial marker, remained constant, but their amounts per muscle decreased in proportion to the atrophy. However, myoglobin concentration increased in plantaris muscles of CA-treated animals, although total myoglobin per muscle was reduced slightly. Myoglobin levels were increased in plantaris muscles both as a result of training and CA, but citrate synthase activity was increased only as a result of the exercise. These results show that exercise can retard the glucocorticoid-induced muscle atrophy.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7282923

Citation

Hickson, R C., and J R. Davis. "Partial Prevention of Glucocorticoid-induced Muscle Atrophy By Endurance Training." The American Journal of Physiology, vol. 241, no. 3, 1981, pp. E226-32.
Hickson RC, Davis JR. Partial prevention of glucocorticoid-induced muscle atrophy by endurance training. Am J Physiol. 1981;241(3):E226-32.
Hickson, R. C., & Davis, J. R. (1981). Partial prevention of glucocorticoid-induced muscle atrophy by endurance training. The American Journal of Physiology, 241(3), E226-32.
Hickson RC, Davis JR. Partial Prevention of Glucocorticoid-induced Muscle Atrophy By Endurance Training. Am J Physiol. 1981;241(3):E226-32. PubMed PMID: 7282923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial prevention of glucocorticoid-induced muscle atrophy by endurance training. AU - Hickson,R C, AU - Davis,J R, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - E226 EP - 32 JF - The American journal of physiology JO - Am J Physiol VL - 241 IS - 3 N2 - Male rats were either sham-operated (N) or castrated (C) at 65 days of age. They were further subdivided into sedentary or exercise groups that were trained by treadmill running 5 days/wk for 12 wk. During the last 10 days of training, the animals received daily subcutaneous injections of cortisone acetate (CA) (100 mg/kg) or 1% carboxymethylcellulose. Body weight decreased approximately 25% in all groups that received CA. The fast-twitch plantaris and gastrocnemius muscle weights were approximately 35% lower in CA-treated versus cortisone-free N and C sedentary animals. Exercise prevented from one-fourth to one-half of the muscle weight loss in N and C runners when compared to their respective pair weight controls. Muscle weights of the CA-treated freely eating N controls were significantly less than that of N runners that received CA. In plantaris muscles of both N and C animals that received CA, total protein concentration and citrate synthase activity, a mitochondrial marker, remained constant, but their amounts per muscle decreased in proportion to the atrophy. However, myoglobin concentration increased in plantaris muscles of CA-treated animals, although total myoglobin per muscle was reduced slightly. Myoglobin levels were increased in plantaris muscles both as a result of training and CA, but citrate synthase activity was increased only as a result of the exercise. These results show that exercise can retard the glucocorticoid-induced muscle atrophy. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/7282923/Partial_prevention_of_glucocorticoid_induced_muscle_atrophy_by_endurance_training_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.1981.241.3.E226?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -