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Comparison of brain serotoninergic systems in C57BL and BALBc mice during development.
J Physiol (Paris). 1981; 77(2-3):315-8.JP

Abstract

Adult C57BL and BALBc mice will exhibit differences in behaviour and in their sleep patterns which may be correlated with monoamine content. In this study, we measured the endogenous levels of serotonin (5-HT), tryptophan (TRP), 5-hydroxyindole acetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA) in the forebrain and hindbrain regions of these strains of mice from day 1 to 12 weeks of age. Using the micropunch technique and a radioenzymatic method, we also determined the endogenous 5-HT levels in the nuclei raphe dorsalis, centralis, magnus-pallidus and obscurus. During development, NA levels in the brain stem are higher in the C57BL than in the BALBc mice. From 5 weeks of age onwards, the levels of 5-HT, DA and NA in the forebrain are also higher in the C57BL mice. However, no differences in 5-Ht and DA content was found for the brain stems of these two strains. When the 5-HT levels in the different raphe nuclei were analyzed, the nucleus raphe dorsalis of the BALBc showed a higher 5-HT content.

Authors

Daszuta A
No affiliation info available
Barrit MC
No affiliation info available
Faudon M
No affiliation info available
Gambarelli F
No affiliation info available

MeSH

AgingAnimalsBrainDopamineMiceMice, Inbred BALB CMice, Inbred C57BLNorepinephrineSerotoninSpecies Specificity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7288648

Citation

Daszuta, A, et al. "Comparison of Brain Serotoninergic Systems in C57BL and BALBc Mice During Development." Journal De Physiologie, vol. 77, no. 2-3, 1981, pp. 315-8.
Daszuta A, Barrit MC, Faudon M, et al. Comparison of brain serotoninergic systems in C57BL and BALBc mice during development. J Physiol (Paris). 1981;77(2-3):315-8.
Daszuta, A., Barrit, M. C., Faudon, M., & Gambarelli, F. (1981). Comparison of brain serotoninergic systems in C57BL and BALBc mice during development. Journal De Physiologie, 77(2-3), 315-8.
Daszuta A, et al. Comparison of Brain Serotoninergic Systems in C57BL and BALBc Mice During Development. J Physiol (Paris). 1981;77(2-3):315-8. PubMed PMID: 7288648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of brain serotoninergic systems in C57BL and BALBc mice during development. AU - Daszuta,A, AU - Barrit,M C, AU - Faudon,M, AU - Gambarelli,F, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 315 EP - 8 JF - Journal de physiologie JO - J Physiol (Paris) VL - 77 IS - 2-3 N2 - Adult C57BL and BALBc mice will exhibit differences in behaviour and in their sleep patterns which may be correlated with monoamine content. In this study, we measured the endogenous levels of serotonin (5-HT), tryptophan (TRP), 5-hydroxyindole acetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA) in the forebrain and hindbrain regions of these strains of mice from day 1 to 12 weeks of age. Using the micropunch technique and a radioenzymatic method, we also determined the endogenous 5-HT levels in the nuclei raphe dorsalis, centralis, magnus-pallidus and obscurus. During development, NA levels in the brain stem are higher in the C57BL than in the BALBc mice. From 5 weeks of age onwards, the levels of 5-HT, DA and NA in the forebrain are also higher in the C57BL mice. However, no differences in 5-Ht and DA content was found for the brain stems of these two strains. When the 5-HT levels in the different raphe nuclei were analyzed, the nucleus raphe dorsalis of the BALBc showed a higher 5-HT content. SN - 0021-7948 UR - https://www.unboundmedicine.com/medline/citation/7288648/Comparison_of_brain_serotoninergic_systems_in_C57BL_and_BALBc_mice_during_development_ DB - PRIME DP - Unbound Medicine ER -