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The influence of binder type and concentration on the physical characteristics of calcium carbonate granules and their corresponding tablets.
Pharmazie. 1981 Aug; 36(8):548-51.P

Abstract

Most studies involving binders are concerned with the properties of the final product. Very little has been done at comparing the mechanical properties of the granules, the force required to crush the tablets and the compression behavior. The aim of this investigation was to study the effect of different concentrations of five binders namely gelatin, PVP, methylcellulose, syrup and Eudragit E on the mechanical and physical properties of calcium carbonate granules and correlating that with the characteristics of the corresponding tablets. A template method was used for the preparation of calcium carbonate granules. The wet granules were dried for 34 h in air oven at 60 degrees C and were conditioned for a minimum of 2 h at 50% relative humidity before testing or tableting as this corresponds approximately to ambient conditions. The granules, were separated into different size fractions using the sieve analysis method, and were then measured for crushing strength (K), friability (%), flow ability, bulk volume and tap density. The granules possessing the best mechanical and physical characteristics were used for tableting. The compact obtained were also evaluated for both mechanical and physical properties. It was found that increasing the binder concentration was followed by an increase in the mean particle diameter, harder granules (-kt = ln Wa divided by W + Wb . db divided by W . da) and reduction in tap density. Except for those prepared with 2% methylcellulose and 30% syrup, all tablets prepared from granules with optimum properties are found to satisfy U.S.P. requirements of weight, thickness, disintegration time and mechanical properties.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7291287

Citation

Elsabbagh, H M., et al. "The Influence of Binder Type and Concentration On the Physical Characteristics of Calcium Carbonate Granules and Their Corresponding Tablets." Die Pharmazie, vol. 36, no. 8, 1981, pp. 548-51.
Elsabbagh HM, Ghanem AH, Abdel-Alim HM. The influence of binder type and concentration on the physical characteristics of calcium carbonate granules and their corresponding tablets. Pharmazie. 1981;36(8):548-51.
Elsabbagh, H. M., Ghanem, A. H., & Abdel-Alim, H. M. (1981). The influence of binder type and concentration on the physical characteristics of calcium carbonate granules and their corresponding tablets. Die Pharmazie, 36(8), 548-51.
Elsabbagh HM, Ghanem AH, Abdel-Alim HM. The Influence of Binder Type and Concentration On the Physical Characteristics of Calcium Carbonate Granules and Their Corresponding Tablets. Pharmazie. 1981;36(8):548-51. PubMed PMID: 7291287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of binder type and concentration on the physical characteristics of calcium carbonate granules and their corresponding tablets. AU - Elsabbagh,H M, AU - Ghanem,A H, AU - Abdel-Alim,H M, PY - 1981/8/1/pubmed PY - 1981/8/1/medline PY - 1981/8/1/entrez SP - 548 EP - 51 JF - Die Pharmazie JO - Pharmazie VL - 36 IS - 8 N2 - Most studies involving binders are concerned with the properties of the final product. Very little has been done at comparing the mechanical properties of the granules, the force required to crush the tablets and the compression behavior. The aim of this investigation was to study the effect of different concentrations of five binders namely gelatin, PVP, methylcellulose, syrup and Eudragit E on the mechanical and physical properties of calcium carbonate granules and correlating that with the characteristics of the corresponding tablets. A template method was used for the preparation of calcium carbonate granules. The wet granules were dried for 34 h in air oven at 60 degrees C and were conditioned for a minimum of 2 h at 50% relative humidity before testing or tableting as this corresponds approximately to ambient conditions. The granules, were separated into different size fractions using the sieve analysis method, and were then measured for crushing strength (K), friability (%), flow ability, bulk volume and tap density. The granules possessing the best mechanical and physical characteristics were used for tableting. The compact obtained were also evaluated for both mechanical and physical properties. It was found that increasing the binder concentration was followed by an increase in the mean particle diameter, harder granules (-kt = ln Wa divided by W + Wb . db divided by W . da) and reduction in tap density. Except for those prepared with 2% methylcellulose and 30% syrup, all tablets prepared from granules with optimum properties are found to satisfy U.S.P. requirements of weight, thickness, disintegration time and mechanical properties. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/7291287/The_influence_of_binder_type_and_concentration_on_the_physical_characteristics_of_calcium_carbonate_granules_and_their_corresponding_tablets_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:7291287 DB - PRIME DP - Unbound Medicine ER -
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