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[Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy].
Schweiz Med Wochenschr. 1981 Sep 26; 111(39):1445-50.SM

Abstract

Adverse reactions (urticaria, angio-edema, bronchoconstriction, purpura) to Aspirin (ASS) and food-and-drug additives such as the yellow dye tartrazine and the preservative benzoate are observed all over the world. Since the exact pathogenetic mechanisms of this condition is unknown, it is described as intolerance or pseudo-allergy and has been related to an imbalance of prostaglandin synthesis. Among 620 patients with urticaria, bronchial asthma or chronic rhinitis, oral provocation tests with ASS, tartrazine or benzoic acid revealed in 165 (26.6%) intolerance to ASS or additives. Frequency of intolerance to tartrazine varied between 6.1% in urticaria (n=308), 7.3% in asthma (n=96) and 14.5% in urticaria and asthma patients, while intolerance to benzoate varied from 2.5% in rhinitis (n=40) to 11.5% in asthma. More than two thirds of the intolerant patients were improved by an elimination diet and by the avoidance of "aspirin-like" drugs. More than one third of chronic urticaria patients became symptomfree. In Switzerland exact declaration of all food additives is urgently needed. Moreover, azo-dyes must no longer be used for colouring of drugs.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

7291963

Citation

Wüthrich, B, and L Fabro. "[Acetylsalicylic Acid and Food Additive Intolerance in Urticaria, Bronchial Asthma and Rhinopathy]." Schweizerische Medizinische Wochenschrift, vol. 111, no. 39, 1981, pp. 1445-50.
Wüthrich B, Fabro L. [Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy]. Schweiz Med Wochenschr. 1981;111(39):1445-50.
Wüthrich, B., & Fabro, L. (1981). [Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy]. Schweizerische Medizinische Wochenschrift, 111(39), 1445-50.
Wüthrich B, Fabro L. [Acetylsalicylic Acid and Food Additive Intolerance in Urticaria, Bronchial Asthma and Rhinopathy]. Schweiz Med Wochenschr. 1981 Sep 26;111(39):1445-50. PubMed PMID: 7291963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy]. AU - Wüthrich,B, AU - Fabro,L, PY - 1981/9/26/pubmed PY - 1981/9/26/medline PY - 1981/9/26/entrez SP - 1445 EP - 50 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 111 IS - 39 N2 - Adverse reactions (urticaria, angio-edema, bronchoconstriction, purpura) to Aspirin (ASS) and food-and-drug additives such as the yellow dye tartrazine and the preservative benzoate are observed all over the world. Since the exact pathogenetic mechanisms of this condition is unknown, it is described as intolerance or pseudo-allergy and has been related to an imbalance of prostaglandin synthesis. Among 620 patients with urticaria, bronchial asthma or chronic rhinitis, oral provocation tests with ASS, tartrazine or benzoic acid revealed in 165 (26.6%) intolerance to ASS or additives. Frequency of intolerance to tartrazine varied between 6.1% in urticaria (n=308), 7.3% in asthma (n=96) and 14.5% in urticaria and asthma patients, while intolerance to benzoate varied from 2.5% in rhinitis (n=40) to 11.5% in asthma. More than two thirds of the intolerant patients were improved by an elimination diet and by the avoidance of "aspirin-like" drugs. More than one third of chronic urticaria patients became symptomfree. In Switzerland exact declaration of all food additives is urgently needed. Moreover, azo-dyes must no longer be used for colouring of drugs. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/7291963/[Acetylsalicylic_acid_and_food_additive_intolerance_in_urticaria_bronchial_asthma_and_rhinopathy]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -