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Effects of glycerol on sodium and potassium concentrations in guinea pig perilymph.
Arch Otorhinolaryngol. 1981; 230(2):177-80.AO

Abstract

Serum, cerebrospinal fluid (CSF), scala vestibuli perilymph, and scala tympani perilymph were collected from 85 normal guinea pigs both before and after i.v. administration of glycerol (1 ml/kg), and the sodium and potassium concentrations were assessed using a microflame photometer. Marked increases in sodium concentrations were observed in scala tympani perilymph and CSF, while there was a slight decrease in the serum and there was no significant change in scala vestibuli perilymph. These increases in sodium concentrations are considered to occur in the dehydration process in the body fluids mentioned above. On the other hand, increase in the potassium concentrations was found only in scala vestibuli perilymph and thus cannot be explained by simple dehydration process. This potassium elevation in scala vestibuli perilymph should be understood by further experiment on endolymph. It became evident that scala vestibuli perilymph differs from scala tympani perilymph and CSF in the dynamics of electrolytes after glycerol administration. In this regard, the nature of the scala vestibuli as fluid space should be studied in future. The above findings obtained in the present study may imply the significance in elucidating the glycerol effect on hearing of endolymphatic hydrops case.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7295177

Citation

Kanoh, N, et al. "Effects of Glycerol On Sodium and Potassium Concentrations in Guinea Pig Perilymph." Archives of Oto-rhino-laryngology, vol. 230, no. 2, 1981, pp. 177-80.
Kanoh N, Yagi N, Omura M, et al. Effects of glycerol on sodium and potassium concentrations in guinea pig perilymph. Arch Otorhinolaryngol. 1981;230(2):177-80.
Kanoh, N., Yagi, N., Omura, M., & Makimoto, K. (1981). Effects of glycerol on sodium and potassium concentrations in guinea pig perilymph. Archives of Oto-rhino-laryngology, 230(2), 177-80.
Kanoh N, et al. Effects of Glycerol On Sodium and Potassium Concentrations in Guinea Pig Perilymph. Arch Otorhinolaryngol. 1981;230(2):177-80. PubMed PMID: 7295177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of glycerol on sodium and potassium concentrations in guinea pig perilymph. AU - Kanoh,N, AU - Yagi,N, AU - Omura,M, AU - Makimoto,K, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 177 EP - 80 JF - Archives of oto-rhino-laryngology JO - Arch Otorhinolaryngol VL - 230 IS - 2 N2 - Serum, cerebrospinal fluid (CSF), scala vestibuli perilymph, and scala tympani perilymph were collected from 85 normal guinea pigs both before and after i.v. administration of glycerol (1 ml/kg), and the sodium and potassium concentrations were assessed using a microflame photometer. Marked increases in sodium concentrations were observed in scala tympani perilymph and CSF, while there was a slight decrease in the serum and there was no significant change in scala vestibuli perilymph. These increases in sodium concentrations are considered to occur in the dehydration process in the body fluids mentioned above. On the other hand, increase in the potassium concentrations was found only in scala vestibuli perilymph and thus cannot be explained by simple dehydration process. This potassium elevation in scala vestibuli perilymph should be understood by further experiment on endolymph. It became evident that scala vestibuli perilymph differs from scala tympani perilymph and CSF in the dynamics of electrolytes after glycerol administration. In this regard, the nature of the scala vestibuli as fluid space should be studied in future. The above findings obtained in the present study may imply the significance in elucidating the glycerol effect on hearing of endolymphatic hydrops case. SN - 0302-9530 UR - https://www.unboundmedicine.com/medline/citation/7295177/Effects_of_glycerol_on_sodium_and_potassium_concentrations_in_guinea_pig_perilymph_ L2 - https://medlineplus.gov/potassium.html DB - PRIME DP - Unbound Medicine ER -