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Metabolic insufficiency as a limiting factor in the dietetic treatment of obesity.
Horm Metab Res. 1981 Sep; 13(9):477-9.HM

Abstract

Previous observations that acute total fasting decreases serum T3 and increase rT3 has prompted the following study. 17 obese women were placed on a 1000 kcal/day weight-reducing diet, and body weight (BW), serum T4, RT3U, T3, rT3, TSH and the Achilles tendon reflex (ATR) were estimated before and after each month for 3 consecutive months of the diet. The results showed a consistent decrease in serum T3, and inconsistent increase in rT3, a consistent prolongation of the ATR and a levelling-off of the BW loss after the second month of the diet. At 3 months there was a negative correlation between the decrease in BW and the increase in ATR, i.e. the more abnormal the ATR became, the less weight the patient lost. It is concluded: 1) Even a moderate hypocaloric diet in ambulatory patients induces a disturbance in the peripheral conversion of T4 to T3 and a secondary state of metabolic insufficiency. 2). This insufficiency is probable related to the observed tendency of the BW loss to level off after two months. 3) A controlled trial of physiologic doses of T3, such as 40 mu g/day, seems indicated, as opposed to pharmacologic dosed of T3 used by previous investigators.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7298016

Citation

Kitsopanides, J, et al. "Metabolic Insufficiency as a Limiting Factor in the Dietetic Treatment of Obesity." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 13, no. 9, 1981, pp. 477-9.
Kitsopanides J, Koutras DA, Souvatzoglou A, et al. Metabolic insufficiency as a limiting factor in the dietetic treatment of obesity. Horm Metab Res. 1981;13(9):477-9.
Kitsopanides, J., Koutras, D. A., Souvatzoglou, A., Boukis, M., Piperingos, G. D., Sfontouris, J., & Moulopoulos, S. D. (1981). Metabolic insufficiency as a limiting factor in the dietetic treatment of obesity. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 13(9), 477-9.
Kitsopanides J, et al. Metabolic Insufficiency as a Limiting Factor in the Dietetic Treatment of Obesity. Horm Metab Res. 1981;13(9):477-9. PubMed PMID: 7298016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic insufficiency as a limiting factor in the dietetic treatment of obesity. AU - Kitsopanides,J, AU - Koutras,D A, AU - Souvatzoglou,A, AU - Boukis,M, AU - Piperingos,G D, AU - Sfontouris,J, AU - Moulopoulos,S D, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - 477 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 13 IS - 9 N2 - Previous observations that acute total fasting decreases serum T3 and increase rT3 has prompted the following study. 17 obese women were placed on a 1000 kcal/day weight-reducing diet, and body weight (BW), serum T4, RT3U, T3, rT3, TSH and the Achilles tendon reflex (ATR) were estimated before and after each month for 3 consecutive months of the diet. The results showed a consistent decrease in serum T3, and inconsistent increase in rT3, a consistent prolongation of the ATR and a levelling-off of the BW loss after the second month of the diet. At 3 months there was a negative correlation between the decrease in BW and the increase in ATR, i.e. the more abnormal the ATR became, the less weight the patient lost. It is concluded: 1) Even a moderate hypocaloric diet in ambulatory patients induces a disturbance in the peripheral conversion of T4 to T3 and a secondary state of metabolic insufficiency. 2). This insufficiency is probable related to the observed tendency of the BW loss to level off after two months. 3) A controlled trial of physiologic doses of T3, such as 40 mu g/day, seems indicated, as opposed to pharmacologic dosed of T3 used by previous investigators. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7298016/Metabolic_insufficiency_as_a_limiting_factor_in_the_dietetic_treatment_of_obesity_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1019310 DB - PRIME DP - Unbound Medicine ER -