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Steep gradients of amino acids between cochlear endolymph and perilymph.
Laryngoscope. 1981 Nov; 91(11):1785-91.L

Abstract

Levels of 19 free amino acids in cochlear endolymph and perilymph of scala vestibuli of the guinea pig were determined using reverse phase high performance liquid chromatography (HPLC) of the o-phthaldialdehyde-ethanethiol derivatives with fluorescence detection. Aspartate and glutamate were found to be significantly higher in endolymph than in perilymph, confirming results from another study using a different analytical method. The remaining 17 amino acids were significantly lower in the endolymph, in many cases by an order of magnitude. The data are compared with results on utricular endolymph and vestibular perilymph obtained by HPLC in another study from our laboratory. Possible implications and interpretations of the results are discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7300529

Citation

Thalmann, R, et al. "Steep Gradients of Amino Acids Between Cochlear Endolymph and Perilymph." The Laryngoscope, vol. 91, no. 11, 1981, pp. 1785-91.
Thalmann R, Comegys TH, DeMott JE, et al. Steep gradients of amino acids between cochlear endolymph and perilymph. Laryngoscope. 1981;91(11):1785-91.
Thalmann, R., Comegys, T. H., DeMott, J. E., & Thalmann, I. (1981). Steep gradients of amino acids between cochlear endolymph and perilymph. The Laryngoscope, 91(11), 1785-91.
Thalmann R, et al. Steep Gradients of Amino Acids Between Cochlear Endolymph and Perilymph. Laryngoscope. 1981;91(11):1785-91. PubMed PMID: 7300529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steep gradients of amino acids between cochlear endolymph and perilymph. AU - Thalmann,R, AU - Comegys,T H, AU - DeMott,J E, AU - Thalmann,I, PY - 1981/11/1/pubmed PY - 1981/11/1/medline PY - 1981/11/1/entrez SP - 1785 EP - 91 JF - The Laryngoscope JO - Laryngoscope VL - 91 IS - 11 N2 - Levels of 19 free amino acids in cochlear endolymph and perilymph of scala vestibuli of the guinea pig were determined using reverse phase high performance liquid chromatography (HPLC) of the o-phthaldialdehyde-ethanethiol derivatives with fluorescence detection. Aspartate and glutamate were found to be significantly higher in endolymph than in perilymph, confirming results from another study using a different analytical method. The remaining 17 amino acids were significantly lower in the endolymph, in many cases by an order of magnitude. The data are compared with results on utricular endolymph and vestibular perilymph obtained by HPLC in another study from our laboratory. Possible implications and interpretations of the results are discussed. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/7300529/Steep_gradients_of_amino_acids_between_cochlear_endolymph_and_perilymph_ L2 - https://doi.org/10.1288/00005537-198111000-00001 DB - PRIME DP - Unbound Medicine ER -