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[Surgery of Zollinger-Ellison syndrome].
Minerva Chir. 1981 Oct 31; 36(20):1291-302.MC

Abstract

Two personal cases of Zollinger-Ellison syndrome (ZES) are described. Total gastrectomy (TG) was performed in the first case as an emergency measure, following acute peritonitis caused by a recurrence of ulcer, with perforation 27 days after the first gastric resection. The patients is in good health, though with persistently high blood gastrin levels. The second case was marked by a long history of recurrent ulcer, with two earlier gastric resections. Here, success was obtained by simply enucleating a small gastrinoma from the head of the pancreas in view of the arteriographic evidence. The patient is in excellent health 2 1/2 yr after surgery with stable, normal blood gastrin. The recent literature and these cases suggest that surgery is the method of choice for ZES, its primary aim being the removal of gastrinomas, since these prove malignant in 60-100% of cases, and TG does not in any way inhibit their growth, as was once supposed. Blood gastrin values permit early diagnosis and postoperative monitoring, while arteriography and transhepatic portal catheterisation constitute a useful guide to the location of the tumour. Hyperchlorhydria can be effectively controlled with H2 receptor inhibitors, both in the preoperative diagnostic stage, and after surgery in the event of failure. TG offers the best results in over 60% of cases, when the tumours is multifocal, widely metastasised, or undiscoverable.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ita

PubMed ID

7301147

Citation

Procacciante, F, et al. "[Surgery of Zollinger-Ellison Syndrome]." Minerva Chirurgica, vol. 36, no. 20, 1981, pp. 1291-302.
Procacciante F, Citone G, Guaitoli P, et al. [Surgery of Zollinger-Ellison syndrome]. Minerva Chir. 1981;36(20):1291-302.
Procacciante, F., Citone, G., Guaitoli, P., Montesani, C., & Ribotta, G. (1981). [Surgery of Zollinger-Ellison syndrome]. Minerva Chirurgica, 36(20), 1291-302.
Procacciante F, et al. [Surgery of Zollinger-Ellison Syndrome]. Minerva Chir. 1981 Oct 31;36(20):1291-302. PubMed PMID: 7301147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Surgery of Zollinger-Ellison syndrome]. AU - Procacciante,F, AU - Citone,G, AU - Guaitoli,P, AU - Montesani,C, AU - Ribotta,G, PY - 1981/10/31/pubmed PY - 1981/10/31/medline PY - 1981/10/31/entrez SP - 1291 EP - 302 JF - Minerva chirurgica JO - Minerva Chir VL - 36 IS - 20 N2 - Two personal cases of Zollinger-Ellison syndrome (ZES) are described. Total gastrectomy (TG) was performed in the first case as an emergency measure, following acute peritonitis caused by a recurrence of ulcer, with perforation 27 days after the first gastric resection. The patients is in good health, though with persistently high blood gastrin levels. The second case was marked by a long history of recurrent ulcer, with two earlier gastric resections. Here, success was obtained by simply enucleating a small gastrinoma from the head of the pancreas in view of the arteriographic evidence. The patient is in excellent health 2 1/2 yr after surgery with stable, normal blood gastrin. The recent literature and these cases suggest that surgery is the method of choice for ZES, its primary aim being the removal of gastrinomas, since these prove malignant in 60-100% of cases, and TG does not in any way inhibit their growth, as was once supposed. Blood gastrin values permit early diagnosis and postoperative monitoring, while arteriography and transhepatic portal catheterisation constitute a useful guide to the location of the tumour. Hyperchlorhydria can be effectively controlled with H2 receptor inhibitors, both in the preoperative diagnostic stage, and after surgery in the event of failure. TG offers the best results in over 60% of cases, when the tumours is multifocal, widely metastasised, or undiscoverable. SN - 0026-4733 UR - https://www.unboundmedicine.com/medline/citation/7301147/[Surgery_of_Zollinger_Ellison_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -