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On the role of dopamine receptors in the central regulation of human TSH.
Acta Endocrinol (Copenh). 1981 Dec; 98(4):521-7.AE

Abstract

The effects of acute administration of haloperidol (4 mg im) and pimozide (4 mg orally) on TSH and Prl secretion were studied in normal and hypothyroid man. The TRH-induced TSH secretion before and after pre-medication with pimozide and domperidone, a peripheral dopamine (DA) blocker, was also evaluated in a group of normal subjects. Haloperidol and pimozide induced a marked increment in serum Prl; mean Prl levels were still significantly elevated 12 h following pimozide administration. A small but significant TSH increase was observed following haloperidol and pimozide in normal as well as hypothyroid subjects. Both domperidone and pimozide significantly enhanced TRH-induced TSH release. In another experiment 3 women with primary thyroid failure received an infusion of DA (4 micrograms/kg/min for 4 h) with and without domperidone administration. TSH and Prl levels were suppressed by DA, but the effect was completely abolished by domperidone. The results suggest that psychotrophic drugs, such as haloperidol and pimozide, can, like substituted benzamides, stimulate TSH release in man. Since domperidone and DA do not cross the blood-brain-barrier and domperidone significantly enhanced the TSH response to TRH, the data also support the hypothesis that human TSH is regulated by DA at the hypothalamus (median eminence) and/or pituitary level.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7304078

Citation

Delitala, G, et al. "On the Role of Dopamine Receptors in the Central Regulation of Human TSH." Acta Endocrinologica, vol. 98, no. 4, 1981, pp. 521-7.
Delitala G, Devilla L, Canessa A, et al. On the role of dopamine receptors in the central regulation of human TSH. Acta Endocrinol (Copenh). 1981;98(4):521-7.
Delitala, G., Devilla, L., Canessa, A., & D'Asta, F. (1981). On the role of dopamine receptors in the central regulation of human TSH. Acta Endocrinologica, 98(4), 521-7.
Delitala G, et al. On the Role of Dopamine Receptors in the Central Regulation of Human TSH. Acta Endocrinol (Copenh). 1981;98(4):521-7. PubMed PMID: 7304078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the role of dopamine receptors in the central regulation of human TSH. AU - Delitala,G, AU - Devilla,L, AU - Canessa,A, AU - D'Asta,F, PY - 1981/12/1/pubmed PY - 1981/12/1/medline PY - 1981/12/1/entrez SP - 521 EP - 7 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 98 IS - 4 N2 - The effects of acute administration of haloperidol (4 mg im) and pimozide (4 mg orally) on TSH and Prl secretion were studied in normal and hypothyroid man. The TRH-induced TSH secretion before and after pre-medication with pimozide and domperidone, a peripheral dopamine (DA) blocker, was also evaluated in a group of normal subjects. Haloperidol and pimozide induced a marked increment in serum Prl; mean Prl levels were still significantly elevated 12 h following pimozide administration. A small but significant TSH increase was observed following haloperidol and pimozide in normal as well as hypothyroid subjects. Both domperidone and pimozide significantly enhanced TRH-induced TSH release. In another experiment 3 women with primary thyroid failure received an infusion of DA (4 micrograms/kg/min for 4 h) with and without domperidone administration. TSH and Prl levels were suppressed by DA, but the effect was completely abolished by domperidone. The results suggest that psychotrophic drugs, such as haloperidol and pimozide, can, like substituted benzamides, stimulate TSH release in man. Since domperidone and DA do not cross the blood-brain-barrier and domperidone significantly enhanced the TSH response to TRH, the data also support the hypothesis that human TSH is regulated by DA at the hypothalamus (median eminence) and/or pituitary level. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/7304078/On_the_role_of_dopamine_receptors_in_the_central_regulation_of_human_TSH_ DB - PRIME DP - Unbound Medicine ER -