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Phenytoin disposition in smokers and nonsmokers.
Int J Clin Pharmacol Biopharm. 1978 Nov; 16(11):547-50.IJ

Abstract

Smoking habit did not affect the disposition kinetics of intravenously administered phenytoin. Phenyoin was given to 8 smokers and 8 nonsmokers and plasma concentrations of phenytoin were determined over a three day period by GLC and RIA techniques. Nonlinear least squares computer fit of the plasma concentration-time data yielded coefficients of a biexponential equation for calculation of half-lives (t1/2beta), clearances (ClB) and volumes of distribution. There were no statistically significant differences in these parameters with respect to either sex or smoking habit. However, more variable t1/2beta's were noted in the smoking group. No differences in serum protein binding between smoking and nonsmoking groups were found. Serum thiocyanate concentrations were used as a measure of smoking habit. There was no significant correlation between thiocyanate concentrations and t1/2beta or ClB. Attemps to correlate phenytoin ClB with basal metabolic rate also failed.

Authors

Rose JQ
No affiliation info available
Barron SA
No affiliation info available
Jusko WJ
No affiliation info available

MeSH

AdultAgedBlood ProteinsFemaleHalf-LifeHumansKineticsMaleMiddle AgedOxygen ConsumptionPhenytoinProtein BindingSmokingThiocyanatesTime Factors

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

730422

Citation

Rose, J Q., et al. "Phenytoin Disposition in Smokers and Nonsmokers." International Journal of Clinical Pharmacology and Biopharmacy, vol. 16, no. 11, 1978, pp. 547-50.
Rose JQ, Barron SA, Jusko WJ. Phenytoin disposition in smokers and nonsmokers. Int J Clin Pharmacol Biopharm. 1978;16(11):547-50.
Rose, J. Q., Barron, S. A., & Jusko, W. J. (1978). Phenytoin disposition in smokers and nonsmokers. International Journal of Clinical Pharmacology and Biopharmacy, 16(11), 547-50.
Rose JQ, Barron SA, Jusko WJ. Phenytoin Disposition in Smokers and Nonsmokers. Int J Clin Pharmacol Biopharm. 1978;16(11):547-50. PubMed PMID: 730422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenytoin disposition in smokers and nonsmokers. AU - Rose,J Q, AU - Barron,S A, AU - Jusko,W J, PY - 1978/11/1/pubmed PY - 1978/11/1/medline PY - 1978/11/1/entrez SP - 547 EP - 50 JF - International journal of clinical pharmacology and biopharmacy JO - Int J Clin Pharmacol Biopharm VL - 16 IS - 11 N2 - Smoking habit did not affect the disposition kinetics of intravenously administered phenytoin. Phenyoin was given to 8 smokers and 8 nonsmokers and plasma concentrations of phenytoin were determined over a three day period by GLC and RIA techniques. Nonlinear least squares computer fit of the plasma concentration-time data yielded coefficients of a biexponential equation for calculation of half-lives (t1/2beta), clearances (ClB) and volumes of distribution. There were no statistically significant differences in these parameters with respect to either sex or smoking habit. However, more variable t1/2beta's were noted in the smoking group. No differences in serum protein binding between smoking and nonsmoking groups were found. Serum thiocyanate concentrations were used as a measure of smoking habit. There was no significant correlation between thiocyanate concentrations and t1/2beta or ClB. Attemps to correlate phenytoin ClB with basal metabolic rate also failed. SN - 0340-0026 UR - https://www.unboundmedicine.com/medline/citation/730422/Phenytoin_disposition_in_smokers_and_nonsmokers_ DB - PRIME DP - Unbound Medicine ER -