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Temperature-sensitive alteration in fusion activity of subacute sclerosing panencephalitis virus during serial passages in vitro and expression of hemagglutinin on the infected cells.
Biken J. 1981 Jun; 24(1-2):89-94.BJ

Abstract

The Biken strain of subacute sclerosing panencephalitis (SSPE) virus, a maturation-defective variant of measles virus, was serially passed in human embryonic lung (HEL) cells at 37 C. The strain formed syncytial giant cells (GC) at both 37 C and 39 C, but the surface of infected cells did not show hemadsorption at early passages of the strain. However, GC-forming activity of the strain diminished at 39 C after 25 passages or more and hemadsorption on the infected cells became positive at both 37 C and 39 C after 40 passages or more of the strain. Hardly any infectious cell-free virus was detected in the culture fluid even after hemadsorption became positive. Possible mechanisms for the defect of SSPE virus were discussed.

Authors

Ueda S
No affiliation info available

MeSH

Cell FusionCell LineCytopathogenic Effect, ViralHemadsorptionHemagglutinins, ViralHumansSSPE VirusTemperature

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7305888

Citation

Ueda, S. "Temperature-sensitive Alteration in Fusion Activity of Subacute Sclerosing Panencephalitis Virus During Serial Passages in Vitro and Expression of Hemagglutinin On the Infected Cells." Biken Journal, vol. 24, no. 1-2, 1981, pp. 89-94.
Ueda S. Temperature-sensitive alteration in fusion activity of subacute sclerosing panencephalitis virus during serial passages in vitro and expression of hemagglutinin on the infected cells. Biken J. 1981;24(1-2):89-94.
Ueda, S. (1981). Temperature-sensitive alteration in fusion activity of subacute sclerosing panencephalitis virus during serial passages in vitro and expression of hemagglutinin on the infected cells. Biken Journal, 24(1-2), 89-94.
Ueda S. Temperature-sensitive Alteration in Fusion Activity of Subacute Sclerosing Panencephalitis Virus During Serial Passages in Vitro and Expression of Hemagglutinin On the Infected Cells. Biken J. 1981;24(1-2):89-94. PubMed PMID: 7305888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temperature-sensitive alteration in fusion activity of subacute sclerosing panencephalitis virus during serial passages in vitro and expression of hemagglutinin on the infected cells. A1 - Ueda,S, PY - 1981/6/1/pubmed PY - 1981/6/1/medline PY - 1981/6/1/entrez SP - 89 EP - 94 JF - Biken journal JO - Biken J VL - 24 IS - 1-2 N2 - The Biken strain of subacute sclerosing panencephalitis (SSPE) virus, a maturation-defective variant of measles virus, was serially passed in human embryonic lung (HEL) cells at 37 C. The strain formed syncytial giant cells (GC) at both 37 C and 39 C, but the surface of infected cells did not show hemadsorption at early passages of the strain. However, GC-forming activity of the strain diminished at 39 C after 25 passages or more and hemadsorption on the infected cells became positive at both 37 C and 39 C after 40 passages or more of the strain. Hardly any infectious cell-free virus was detected in the culture fluid even after hemadsorption became positive. Possible mechanisms for the defect of SSPE virus were discussed. SN - 0006-2324 UR - https://www.unboundmedicine.com/medline/citation/7305888/Temperature_sensitive_alteration_in_fusion_activity_of_subacute_sclerosing_panencephalitis_virus_during_serial_passages_in_vitro_and_expression_of_hemagglutinin_on_the_infected_cells_ L2 - http://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -