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Zinc protoporphyrin in blood as a biological indicator of chronic lead intoxication.
J Environ Pathol Toxicol. 1978 Jul-Aug; 1(6):897-910.JE

Abstract

Traditionally, the diagnosis of lead intoxication has relied upon blood lead and urine lead determinations. However, metabolic changes in the biosynthetic pathway of heme as well as damage in other organ systems may occur at blood lead levels hitherto regarded as "safe." Lead intoxication leads to elevated zinc protoporphyrin (ZPP) levels in the blood which can be measured quickly, inexpensively and conveniently on a drop of unprocessed whole blood by means of a dedicated front face fluorometer, called a hematofluorometer. In the present study, ZPP showed a strong correlation with the lead-in-blood level, as well as with signs and symptoms of lead-related disease. It is concluded that zinc protoporphyrin determination offers a preferred primary screening test for lead-exposed populations.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

731185

Citation

Eisinger, J, et al. "Zinc Protoporphyrin in Blood as a Biological Indicator of Chronic Lead Intoxication." Journal of Environmental Pathology and Toxicology, vol. 1, no. 6, 1978, pp. 897-910.
Eisinger J, Blumberg WE, Fischbein A, et al. Zinc protoporphyrin in blood as a biological indicator of chronic lead intoxication. J Environ Pathol Toxicol. 1978;1(6):897-910.
Eisinger, J., Blumberg, W. E., Fischbein, A., Lilis, R., & Selikoff, I. J. (1978). Zinc protoporphyrin in blood as a biological indicator of chronic lead intoxication. Journal of Environmental Pathology and Toxicology, 1(6), 897-910.
Eisinger J, et al. Zinc Protoporphyrin in Blood as a Biological Indicator of Chronic Lead Intoxication. J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):897-910. PubMed PMID: 731185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc protoporphyrin in blood as a biological indicator of chronic lead intoxication. AU - Eisinger,J, AU - Blumberg,W E, AU - Fischbein,A, AU - Lilis,R, AU - Selikoff,I J, PY - 1978/7/1/pubmed PY - 1978/7/1/medline PY - 1978/7/1/entrez SP - 897 EP - 910 JF - Journal of environmental pathology and toxicology JO - J Environ Pathol Toxicol VL - 1 IS - 6 N2 - Traditionally, the diagnosis of lead intoxication has relied upon blood lead and urine lead determinations. However, metabolic changes in the biosynthetic pathway of heme as well as damage in other organ systems may occur at blood lead levels hitherto regarded as "safe." Lead intoxication leads to elevated zinc protoporphyrin (ZPP) levels in the blood which can be measured quickly, inexpensively and conveniently on a drop of unprocessed whole blood by means of a dedicated front face fluorometer, called a hematofluorometer. In the present study, ZPP showed a strong correlation with the lead-in-blood level, as well as with signs and symptoms of lead-related disease. It is concluded that zinc protoporphyrin determination offers a preferred primary screening test for lead-exposed populations. SN - 0146-4779 UR - https://www.unboundmedicine.com/medline/citation/731185/Zinc_protoporphyrin_in_blood_as_a_biological_indicator_of_chronic_lead_intoxication_ DB - PRIME DP - Unbound Medicine ER -