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Nitrite as antidote for acute hydrogen sulfide intoxication?
Am Ind Hyg Assoc J 1981; 42(11):805-9AI

Abstract

The detoxification of hydrogen sulfide (H2S) by a heme catalyzed oxidation was examined as part of an on-going study of H2S toxicity. Interlocking O2 absorption and sulfide depletion data indicate that both oxyhemoglobin and methemoglobin are effective catalytic agents. Although the latter is more efficacious, the life time of excess sulfide in the presence of oxygen and either of the above is of the order of minutes. It has also been established that the formation of methemoglobin following nitrite administration occurs preferentially under oxygen poor conditions. Under an atmospheric or oxygen enriched environment, which favors sulfide depletion, the nitrite retards sulfide oxidation. Thus nitrite as an antidote for acute H2S intoxication can only be effective within the first few minutes after the exposure, at which time resuscitation and/or ventilation of the victim is likely to produce conditions in which the nitrite actually slows sulfide removal.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7315740

Citation

Beck, J F., et al. "Nitrite as Antidote for Acute Hydrogen Sulfide Intoxication?" American Industrial Hygiene Association Journal, vol. 42, no. 11, 1981, pp. 805-9.
Beck JF, Bradbury CM, Connors AJ, et al. Nitrite as antidote for acute hydrogen sulfide intoxication? Am Ind Hyg Assoc J. 1981;42(11):805-9.
Beck, J. F., Bradbury, C. M., Connors, A. J., & Donini, J. C. (1981). Nitrite as antidote for acute hydrogen sulfide intoxication? American Industrial Hygiene Association Journal, 42(11), pp. 805-9.
Beck JF, et al. Nitrite as Antidote for Acute Hydrogen Sulfide Intoxication. Am Ind Hyg Assoc J. 1981;42(11):805-9. PubMed PMID: 7315740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitrite as antidote for acute hydrogen sulfide intoxication? AU - Beck,J F, AU - Bradbury,C M, AU - Connors,A J, AU - Donini,J C, PY - 1981/11/1/pubmed PY - 1981/11/1/medline PY - 1981/11/1/entrez SP - 805 EP - 9 JF - American Industrial Hygiene Association journal JO - Am Ind Hyg Assoc J VL - 42 IS - 11 N2 - The detoxification of hydrogen sulfide (H2S) by a heme catalyzed oxidation was examined as part of an on-going study of H2S toxicity. Interlocking O2 absorption and sulfide depletion data indicate that both oxyhemoglobin and methemoglobin are effective catalytic agents. Although the latter is more efficacious, the life time of excess sulfide in the presence of oxygen and either of the above is of the order of minutes. It has also been established that the formation of methemoglobin following nitrite administration occurs preferentially under oxygen poor conditions. Under an atmospheric or oxygen enriched environment, which favors sulfide depletion, the nitrite retards sulfide oxidation. Thus nitrite as an antidote for acute H2S intoxication can only be effective within the first few minutes after the exposure, at which time resuscitation and/or ventilation of the victim is likely to produce conditions in which the nitrite actually slows sulfide removal. SN - 0002-8894 UR - https://www.unboundmedicine.com/medline/citation/7315740/Nitrite_as_antidote_for_acute_hydrogen_sulfide_intoxication DB - PRIME DP - Unbound Medicine ER -