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[Genetic differences in the anticonvulsant effect and rate of metabolism of phenazepam].
Biull Eksp Biol Med. 1981 Oct; 91(10):450-3.BE

Abstract

The metabolic rate of 14C-phenazepam (14 mg/kg) in male C57BL/6 and BALB/c mice and F1 hybrids (BALB/c X C57BL/6) and the anticonvulsant effect of the tranquilizer in hybrid mice were studied. It was demonstrated that oxidation of the phenazepam molecule in the third position in BALB/c mice and in F1 hybrids proceeded at a higher rate than in C57BL/6 mice. The sensitivity to the anticonvulsant effect of phenazepam in C57BL/6 animals was greater than in BALB/c mice and F1 hybrids.

Authors

Seredenin SB
No affiliation info available
Zin'kovskiĭ VG
No affiliation info available
Badyshtov BA
No affiliation info available
Golovenko NIa
No affiliation info available
Rybina IV
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsAnticonvulsantsBenzodiazepinesBenzodiazepinonesBrainHybridization, GeneticLiverMaleMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Biology

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

7317605

Citation

Seredenin, S B., et al. "[Genetic Differences in the Anticonvulsant Effect and Rate of Metabolism of Phenazepam]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 91, no. 10, 1981, pp. 450-3.
Seredenin SB, Zin'kovskiĭ VG, Badyshtov BA, et al. [Genetic differences in the anticonvulsant effect and rate of metabolism of phenazepam]. Biull Eksp Biol Med. 1981;91(10):450-3.
Seredenin, S. B., Zin'kovskiĭ, V. G., Badyshtov, B. A., Golovenko, N. I. a., & Rybina, I. V. (1981). [Genetic differences in the anticonvulsant effect and rate of metabolism of phenazepam]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 91(10), 450-3.
Seredenin SB, et al. [Genetic Differences in the Anticonvulsant Effect and Rate of Metabolism of Phenazepam]. Biull Eksp Biol Med. 1981;91(10):450-3. PubMed PMID: 7317605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic differences in the anticonvulsant effect and rate of metabolism of phenazepam]. AU - Seredenin,S B, AU - Zin'kovskiĭ,V G, AU - Badyshtov,B A, AU - Golovenko,N Ia, AU - Rybina,I V, PY - 1981/10/1/pubmed PY - 1981/10/1/medline PY - 1981/10/1/entrez SP - 450 EP - 3 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 91 IS - 10 N2 - The metabolic rate of 14C-phenazepam (14 mg/kg) in male C57BL/6 and BALB/c mice and F1 hybrids (BALB/c X C57BL/6) and the anticonvulsant effect of the tranquilizer in hybrid mice were studied. It was demonstrated that oxidation of the phenazepam molecule in the third position in BALB/c mice and in F1 hybrids proceeded at a higher rate than in C57BL/6 mice. The sensitivity to the anticonvulsant effect of phenazepam in C57BL/6 animals was greater than in BALB/c mice and F1 hybrids. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/7317605/[Genetic_differences_in_the_anticonvulsant_effect_and_rate_of_metabolism_of_phenazepam]_ DB - PRIME DP - Unbound Medicine ER -