Tags

Type your tag names separated by a space and hit enter

The construction and uses of factorial designs in the preparation of solid dosage forms. Part 3. Effect of temperature and time on the mechanical properties of sintered tablets.
Pharmazie. 1981 Nov; 36(11):772-5.P

Abstract

The present and forecoming series of experiments illustrate the application of factorial design to the study of the sintering phenomena of pharmaceutical tablets. This part was concerned with the effect of temperature (X1) and time (X2) on the mechanical properties of sintered tablets. A 2 X 2 design was developed for salicylamide tablets with the two factors at two levels, and a 3 X 3 design for phenobarbital tablets with the two factors at three levels. Analysis of variance was used to determine the significant effects. Empirical regression equations were obtained which indicated that the hardness of sintered tablets was markedly improved by using the high level of X1 at the low level of X2 in phenobarbital tablets, and the high levels of both X1 and X2 in salicylamide tablets. The tablets tensile strength was a linear function of X1 and X2, but the interaction effect X1X2 was insignificant. Significant quadratic effects of X2/2 and/or X2/1 were also detected for the mechanical properties of phenobarbital tablets.

Authors

El-Banna HM
No affiliation info available
Boraie N
No affiliation info available
El-Shibini HA
No affiliation info available

MeSH

Drug CompoundingHardnessPhenobarbitalSalicylamidesTabletsTemperatureTensile StrengthTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7323126

Citation

El-Banna, H M., et al. "The Construction and Uses of Factorial Designs in the Preparation of Solid Dosage Forms. Part 3. Effect of Temperature and Time On the Mechanical Properties of Sintered Tablets." Die Pharmazie, vol. 36, no. 11, 1981, pp. 772-5.
El-Banna HM, Boraie N, El-Shibini HA. The construction and uses of factorial designs in the preparation of solid dosage forms. Part 3. Effect of temperature and time on the mechanical properties of sintered tablets. Pharmazie. 1981;36(11):772-5.
El-Banna, H. M., Boraie, N., & El-Shibini, H. A. (1981). The construction and uses of factorial designs in the preparation of solid dosage forms. Part 3. Effect of temperature and time on the mechanical properties of sintered tablets. Die Pharmazie, 36(11), 772-5.
El-Banna HM, Boraie N, El-Shibini HA. The Construction and Uses of Factorial Designs in the Preparation of Solid Dosage Forms. Part 3. Effect of Temperature and Time On the Mechanical Properties of Sintered Tablets. Pharmazie. 1981;36(11):772-5. PubMed PMID: 7323126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The construction and uses of factorial designs in the preparation of solid dosage forms. Part 3. Effect of temperature and time on the mechanical properties of sintered tablets. AU - El-Banna,H M, AU - Boraie,N, AU - El-Shibini,H A, PY - 1981/11/1/pubmed PY - 1981/11/1/medline PY - 1981/11/1/entrez SP - 772 EP - 5 JF - Die Pharmazie JO - Pharmazie VL - 36 IS - 11 N2 - The present and forecoming series of experiments illustrate the application of factorial design to the study of the sintering phenomena of pharmaceutical tablets. This part was concerned with the effect of temperature (X1) and time (X2) on the mechanical properties of sintered tablets. A 2 X 2 design was developed for salicylamide tablets with the two factors at two levels, and a 3 X 3 design for phenobarbital tablets with the two factors at three levels. Analysis of variance was used to determine the significant effects. Empirical regression equations were obtained which indicated that the hardness of sintered tablets was markedly improved by using the high level of X1 at the low level of X2 in phenobarbital tablets, and the high levels of both X1 and X2 in salicylamide tablets. The tablets tensile strength was a linear function of X1 and X2, but the interaction effect X1X2 was insignificant. Significant quadratic effects of X2/2 and/or X2/1 were also detected for the mechanical properties of phenobarbital tablets. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/7323126/The_construction_and_uses_of_factorial_designs_in_the_preparation_of_solid_dosage_forms__Part_3__Effect_of_temperature_and_time_on_the_mechanical_properties_of_sintered_tablets_ DB - PRIME DP - Unbound Medicine ER -