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Leishmaniasis in Brazil: XV. Biochemical distinction of Leishmania mexicana amazonensis, L. braziliensis braziliensis and L. braziliensis guyanensis--aetiological agents of cutaneous leishmaniasis in the Amazon Basin of Brazil.
Trans R Soc Trop Med Hyg. 1981; 75(4):524-9.TR

Abstract

Enzymic profiles of the three known agents of human cutaneous leishmaniasis in the lower Amazon region are compared. Of 14 enzymes, 10 (ASAT, ALAT, GPI, G5PD, MDH, ACON, PEP, HK, MPI and ACP) differentiate Leishmania mexicana amazonensis from L. braziliensis braziliensis or L. braziliensis guyanensis: this supports their taxonomic status as distinct species. In contrast, only slight mobility differences of four enzymes (ASAT, ALAT, PGM, MPI) separate L. b. braziliensis and L. b. guyanensis, which are distinguished biochemically for the first time: this indicates that they are closely related. Four stocks of L. b. panamensis correspond with L. b. guyanensis on mobilities of 10 enzymes (ASAT, ALAT, PGM, GPI, G6PD, MDH, PK, HK, MPI, ACP), although these two subspecies are known to be separable by kinetoplast DNA buoyancies and the enzyme 6PGDH. The generation of practical, regional biochemical keys to the medically important leishmanias is discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7324127

Citation

Miles, M A., et al. "Leishmaniasis in Brazil: XV. Biochemical Distinction of Leishmania Mexicana Amazonensis, L. Braziliensis Braziliensis and L. Braziliensis Guyanensis--aetiological Agents of Cutaneous Leishmaniasis in the Amazon Basin of Brazil." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 75, no. 4, 1981, pp. 524-9.
Miles MA, Lainson R, Shaw JJ, et al. Leishmaniasis in Brazil: XV. Biochemical distinction of Leishmania mexicana amazonensis, L. braziliensis braziliensis and L. braziliensis guyanensis--aetiological agents of cutaneous leishmaniasis in the Amazon Basin of Brazil. Trans R Soc Trop Med Hyg. 1981;75(4):524-9.
Miles, M. A., Lainson, R., Shaw, J. J., Póvoa, M., & de Souza, A. A. (1981). Leishmaniasis in Brazil: XV. Biochemical distinction of Leishmania mexicana amazonensis, L. braziliensis braziliensis and L. braziliensis guyanensis--aetiological agents of cutaneous leishmaniasis in the Amazon Basin of Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75(4), 524-9.
Miles MA, et al. Leishmaniasis in Brazil: XV. Biochemical Distinction of Leishmania Mexicana Amazonensis, L. Braziliensis Braziliensis and L. Braziliensis Guyanensis--aetiological Agents of Cutaneous Leishmaniasis in the Amazon Basin of Brazil. Trans R Soc Trop Med Hyg. 1981;75(4):524-9. PubMed PMID: 7324127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leishmaniasis in Brazil: XV. Biochemical distinction of Leishmania mexicana amazonensis, L. braziliensis braziliensis and L. braziliensis guyanensis--aetiological agents of cutaneous leishmaniasis in the Amazon Basin of Brazil. AU - Miles,M A, AU - Lainson,R, AU - Shaw,J J, AU - Póvoa,M, AU - de Souza,A A, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 524 EP - 9 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 75 IS - 4 N2 - Enzymic profiles of the three known agents of human cutaneous leishmaniasis in the lower Amazon region are compared. Of 14 enzymes, 10 (ASAT, ALAT, GPI, G5PD, MDH, ACON, PEP, HK, MPI and ACP) differentiate Leishmania mexicana amazonensis from L. braziliensis braziliensis or L. braziliensis guyanensis: this supports their taxonomic status as distinct species. In contrast, only slight mobility differences of four enzymes (ASAT, ALAT, PGM, MPI) separate L. b. braziliensis and L. b. guyanensis, which are distinguished biochemically for the first time: this indicates that they are closely related. Four stocks of L. b. panamensis correspond with L. b. guyanensis on mobilities of 10 enzymes (ASAT, ALAT, PGM, GPI, G6PD, MDH, PK, HK, MPI, ACP), although these two subspecies are known to be separable by kinetoplast DNA buoyancies and the enzyme 6PGDH. The generation of practical, regional biochemical keys to the medically important leishmanias is discussed. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/7324127/Leishmaniasis_in_Brazil:_XV__Biochemical_distinction_of_Leishmania_mexicana_amazonensis_L__braziliensis_braziliensis_and_L__braziliensis_guyanensis__aetiological_agents_of_cutaneous_leishmaniasis_in_the_Amazon_Basin_of_Brazil_ L2 - https://academic.oup.com/trstmh/article-lookup/doi/10.1016/0035-9203(81)90191-7 DB - PRIME DP - Unbound Medicine ER -