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Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves.
Am J Vet Res. 1981 Sep; 42(9):1630-7.AJ

Abstract

Erythrocyte protoporphyrin was measured in calves by the free erythrocyte porphyrin (FEP) test. The FEP of 15 healthy calves was 142.8 +/- 32.4 micrograms/dl (mean +/- SD) of packed erythrocytes or 45.6 +/- 10.3 micrograms/dl of whole blood. Biweekly oral lead administration to 3 calves produced a continuous increase of FEP to between 2,800 and 6,033 micrograms/dl of packed erythrocytes after 20 weeks. Fluorescence scans of diluted blood were used to demonstrate that erythrocyte protoporphyrin from lead-poisoned calves was present as an approximately 2:1 mixture of zinc protoporphyrin and free protoporphyrin. Blood lead concentration increased in calves after lead was given (orally), but had greater weekly fluctuations than FEP. Mild anemia developed in 2 of 3 animals late in the experiment. Basophilic stippling of erythrocytes occurred in 1 calf.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7325474

Citation

George, J W., and J R. Duncan. "Erythrocyte Protoporphyrin in Experimental Chronic Lead Poisoning in Calves." American Journal of Veterinary Research, vol. 42, no. 9, 1981, pp. 1630-7.
George JW, Duncan JR. Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves. Am J Vet Res. 1981;42(9):1630-7.
George, J. W., & Duncan, J. R. (1981). Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves. American Journal of Veterinary Research, 42(9), 1630-7.
George JW, Duncan JR. Erythrocyte Protoporphyrin in Experimental Chronic Lead Poisoning in Calves. Am J Vet Res. 1981;42(9):1630-7. PubMed PMID: 7325474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves. AU - George,J W, AU - Duncan,J R, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - 1630 EP - 7 JF - American journal of veterinary research JO - Am J Vet Res VL - 42 IS - 9 N2 - Erythrocyte protoporphyrin was measured in calves by the free erythrocyte porphyrin (FEP) test. The FEP of 15 healthy calves was 142.8 +/- 32.4 micrograms/dl (mean +/- SD) of packed erythrocytes or 45.6 +/- 10.3 micrograms/dl of whole blood. Biweekly oral lead administration to 3 calves produced a continuous increase of FEP to between 2,800 and 6,033 micrograms/dl of packed erythrocytes after 20 weeks. Fluorescence scans of diluted blood were used to demonstrate that erythrocyte protoporphyrin from lead-poisoned calves was present as an approximately 2:1 mixture of zinc protoporphyrin and free protoporphyrin. Blood lead concentration increased in calves after lead was given (orally), but had greater weekly fluctuations than FEP. Mild anemia developed in 2 of 3 animals late in the experiment. Basophilic stippling of erythrocytes occurred in 1 calf. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/7325474/Erythrocyte_protoporphyrin_in_experimental_chronic_lead_poisoning_in_calves_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -