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Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid.
Nuklearmedizin. 1981 Dec; 20(6):279-82.N

Abstract

Labelling yield and radiochemical purity, higher than 95%, of 99mTc-colloid preparations were determined by using the paper chromatography method. Less than 3% of labelled citric acid, added to the preparation as a buffer solution, has been found in 99mTc-sulphur colloid. High radiochemical purity and optimum size of colloid particles has also been proved by biodistribution studies on experimental animals. The analysis performed has shown that more than 50% of 99mTc-colloid preparations excreted by urine is 99mTcO-, the remaining past 50% being protein bound 99mTc. Biological half-time of excretion of the fast phase is the same for both preparations, i.e. 10 min, while for the slow component it is 120 min in 99mTc-S-colloid and 160 min in 99mTc-Sn colloid.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7329810

Citation

Jovanović, V, et al. "Determination of Radiochemical Purity and Pharmacokinetic Parameters of 99mTc-sulphur Colloid and 99mTc-tin Colloid." Nuklearmedizin. Nuclear Medicine, vol. 20, no. 6, 1981, pp. 279-82.
Jovanović V, Konstantinovska D, Milivojević K, et al. Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid. Nuklearmedizin. 1981;20(6):279-82.
Jovanović, V., Konstantinovska, D., Milivojević, K., & Bzenić, J. (1981). Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid. Nuklearmedizin. Nuclear Medicine, 20(6), 279-82.
Jovanović V, et al. Determination of Radiochemical Purity and Pharmacokinetic Parameters of 99mTc-sulphur Colloid and 99mTc-tin Colloid. Nuklearmedizin. 1981;20(6):279-82. PubMed PMID: 7329810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid. AU - Jovanović,V, AU - Konstantinovska,D, AU - Milivojević,K, AU - Bzenić,J, PY - 1981/12/1/pubmed PY - 1981/12/1/medline PY - 1981/12/1/entrez SP - 279 EP - 82 JF - Nuklearmedizin. Nuclear medicine JO - Nuklearmedizin VL - 20 IS - 6 N2 - Labelling yield and radiochemical purity, higher than 95%, of 99mTc-colloid preparations were determined by using the paper chromatography method. Less than 3% of labelled citric acid, added to the preparation as a buffer solution, has been found in 99mTc-sulphur colloid. High radiochemical purity and optimum size of colloid particles has also been proved by biodistribution studies on experimental animals. The analysis performed has shown that more than 50% of 99mTc-colloid preparations excreted by urine is 99mTcO-, the remaining past 50% being protein bound 99mTc. Biological half-time of excretion of the fast phase is the same for both preparations, i.e. 10 min, while for the slow component it is 120 min in 99mTc-S-colloid and 160 min in 99mTc-Sn colloid. SN - 0029-5566 UR - https://www.unboundmedicine.com/medline/citation/7329810/Determination_of_radiochemical_purity_and_pharmacokinetic_parameters_of_99mTc_sulphur_colloid_and_99mTc_tin_colloid_ L2 - https://antibodies.cancer.gov/detail/CPTC-SIGLEC1-1 DB - PRIME DP - Unbound Medicine ER -