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New substances with cytotoxic and antitumor effects. IV. In vitro effect of some veratrum alkaloids and their derivatives on leukemia P388 cells.
Neoplasma. 1981; 28(6):709-14.N

Abstract

Some Veratrum alkaloids and their derivatives exhibited an in vitro cytotoxic effect on leukemia P388 cells, depending on the structure of the skeleton of the molecule, particularly on the type of the heterocycle attached to C-20. Veracintine and 20-(2-methyl-1-pyrrolin-5-yl)-4-pregnen-3-one, which proved to be the most effective, inhibited incorporation of uridine, and to a lesser extent that of L-valine into P388 cells fractions. After a brief reaction (15 min), these substances became irreversibly bound in the P388 cells and stopped their further in vitro proliferation. The cytotoxic effect of veracintine became enhanced by sublethal doses of tubercidine (phase of maximum lethality of G1).

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7339499

Citation

Fuska, J, et al. "New Substances With Cytotoxic and Antitumor Effects. IV. in Vitro Effect of some Veratrum Alkaloids and Their Derivatives On Leukemia P388 Cells." Neoplasma, vol. 28, no. 6, 1981, pp. 709-14.
Fuska J, Fusková A, Vassová A, et al. New substances with cytotoxic and antitumor effects. IV. In vitro effect of some veratrum alkaloids and their derivatives on leukemia P388 cells. Neoplasma. 1981;28(6):709-14.
Fuska, J., Fusková, A., Vassová, A., & Votický, Z. (1981). New substances with cytotoxic and antitumor effects. IV. In vitro effect of some veratrum alkaloids and their derivatives on leukemia P388 cells. Neoplasma, 28(6), 709-14.
Fuska J, et al. New Substances With Cytotoxic and Antitumor Effects. IV. in Vitro Effect of some Veratrum Alkaloids and Their Derivatives On Leukemia P388 Cells. Neoplasma. 1981;28(6):709-14. PubMed PMID: 7339499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New substances with cytotoxic and antitumor effects. IV. In vitro effect of some veratrum alkaloids and their derivatives on leukemia P388 cells. AU - Fuska,J, AU - Fusková,A, AU - Vassová,A, AU - Votický,Z, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 709 EP - 14 JF - Neoplasma JO - Neoplasma VL - 28 IS - 6 N2 - Some Veratrum alkaloids and their derivatives exhibited an in vitro cytotoxic effect on leukemia P388 cells, depending on the structure of the skeleton of the molecule, particularly on the type of the heterocycle attached to C-20. Veracintine and 20-(2-methyl-1-pyrrolin-5-yl)-4-pregnen-3-one, which proved to be the most effective, inhibited incorporation of uridine, and to a lesser extent that of L-valine into P388 cells fractions. After a brief reaction (15 min), these substances became irreversibly bound in the P388 cells and stopped their further in vitro proliferation. The cytotoxic effect of veracintine became enhanced by sublethal doses of tubercidine (phase of maximum lethality of G1). SN - 0028-2685 UR - https://www.unboundmedicine.com/medline/citation/7339499/New_substances_with_cytotoxic_and_antitumor_effects__IV__In_vitro_effect_of_some_veratrum_alkaloids_and_their_derivatives_on_leukemia_P388_cells_ DB - PRIME DP - Unbound Medicine ER -