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Pharmacologic regulation of antigen-induced mediator release from canine lung.
Int Arch Allergy Appl Immunol. 1978; 56(1):39-47.IA

Abstract

The ascaris antigen-induced release of histamine and a slow-reacting substance of anaphylaxis (SRS-A) from passively sensitized fragmented canine lung is further characterized. Histamine and SRS-A were released within 30 sec of antigen challenge, reached a maximum at 7 and 10 min, respectively, and thereafter appeared to remain constant to 30 min. Contractions of guinea pig ileum produced by canine SRS-A were competitively antagonized by the SRS-A antagonist FPL-55712. Indomethacin and deuterium oxide enhanced antigen-induced SRS-A release from canine lung but had little effect on histamine release. The ability of several chemically novel 'antiallergic agents' to inhibit mediator release was evaluated. Inhibition of histamine release, and to a lesser extent SRS-A release, by one of these compounds was shown to vary with time and temperature. It is concluded that fragmented canine lung, while disclosing some qualitative pharmacological differences from other species, is a useful in vitro model of immediate hypersensitivity reactions.

Authors

Krell RD
No affiliation info available
Chakrin LW
No affiliation info available

MeSH

AnimalsAntigensAscarisDeuteriumDogsHistamine H1 AntagonistsHistamine ReleaseIndomethacinLungQuinolinesSRS-ATetrazolesThioxanthenesXanthenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

73521

Citation

Krell, R D., and L W. Chakrin. "Pharmacologic Regulation of Antigen-induced Mediator Release From Canine Lung." International Archives of Allergy and Applied Immunology, vol. 56, no. 1, 1978, pp. 39-47.
Krell RD, Chakrin LW. Pharmacologic regulation of antigen-induced mediator release from canine lung. Int Arch Allergy Appl Immunol. 1978;56(1):39-47.
Krell, R. D., & Chakrin, L. W. (1978). Pharmacologic regulation of antigen-induced mediator release from canine lung. International Archives of Allergy and Applied Immunology, 56(1), 39-47.
Krell RD, Chakrin LW. Pharmacologic Regulation of Antigen-induced Mediator Release From Canine Lung. Int Arch Allergy Appl Immunol. 1978;56(1):39-47. PubMed PMID: 73521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic regulation of antigen-induced mediator release from canine lung. AU - Krell,R D, AU - Chakrin,L W, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 39 EP - 47 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 56 IS - 1 N2 - The ascaris antigen-induced release of histamine and a slow-reacting substance of anaphylaxis (SRS-A) from passively sensitized fragmented canine lung is further characterized. Histamine and SRS-A were released within 30 sec of antigen challenge, reached a maximum at 7 and 10 min, respectively, and thereafter appeared to remain constant to 30 min. Contractions of guinea pig ileum produced by canine SRS-A were competitively antagonized by the SRS-A antagonist FPL-55712. Indomethacin and deuterium oxide enhanced antigen-induced SRS-A release from canine lung but had little effect on histamine release. The ability of several chemically novel 'antiallergic agents' to inhibit mediator release was evaluated. Inhibition of histamine release, and to a lesser extent SRS-A release, by one of these compounds was shown to vary with time and temperature. It is concluded that fragmented canine lung, while disclosing some qualitative pharmacological differences from other species, is a useful in vitro model of immediate hypersensitivity reactions. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/73521/Pharmacologic_regulation_of_antigen_induced_mediator_release_from_canine_lung_ DB - PRIME DP - Unbound Medicine ER -