Tags

Type your tag names separated by a space and hit enter

Presenile cataract formation and decreased activity of galactosemic enzymes.
Arch Ophthalmol 1980; 98(2):269-73AO

Abstract

One hundred forty-seven patients, 144 with advanced cataract formation, had determinations of erythrocyte galactokinase and galactose-1-phosphate uridyl transferase performed. Significant reduction (more than 2 SDs) of one of these enzymes was found in 47.4% of patients 50 years old or less with presenile "idiopathic" bilateral cataracts, 7.1% of other patients with cataracts aged 50 years or less, and 3.8% of patients with cataracts aged 51 years or more. The differences between the group with presenile idiopathic cataracts and the other groups were statistically highly significant (P less than .001). Patients with reduced activity of galactokinase or galactose-1-phosphate uridyl transferase (presumed heterozygotes) compose about 1% of the general population, appear to be more susceptible to idiopathic presenile cataract formation, and may be more prone to secondary cataract formation after a variety of lenticular insults. Dietary restriction of milk and milk products may prevent or delay cataract formation in these individuals.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7352874

Citation

Skalka, H W., and J T. Prchal. "Presenile Cataract Formation and Decreased Activity of Galactosemic Enzymes." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 98, no. 2, 1980, pp. 269-73.
Skalka HW, Prchal JT. Presenile cataract formation and decreased activity of galactosemic enzymes. Arch Ophthalmol. 1980;98(2):269-73.
Skalka, H. W., & Prchal, J. T. (1980). Presenile cataract formation and decreased activity of galactosemic enzymes. Archives of Ophthalmology (Chicago, Ill. : 1960), 98(2), pp. 269-73.
Skalka HW, Prchal JT. Presenile Cataract Formation and Decreased Activity of Galactosemic Enzymes. Arch Ophthalmol. 1980;98(2):269-73. PubMed PMID: 7352874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presenile cataract formation and decreased activity of galactosemic enzymes. AU - Skalka,H W, AU - Prchal,J T, PY - 1980/2/1/pubmed PY - 1980/2/1/medline PY - 1980/2/1/entrez SP - 269 EP - 73 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 98 IS - 2 N2 - One hundred forty-seven patients, 144 with advanced cataract formation, had determinations of erythrocyte galactokinase and galactose-1-phosphate uridyl transferase performed. Significant reduction (more than 2 SDs) of one of these enzymes was found in 47.4% of patients 50 years old or less with presenile "idiopathic" bilateral cataracts, 7.1% of other patients with cataracts aged 50 years or less, and 3.8% of patients with cataracts aged 51 years or more. The differences between the group with presenile idiopathic cataracts and the other groups were statistically highly significant (P less than .001). Patients with reduced activity of galactokinase or galactose-1-phosphate uridyl transferase (presumed heterozygotes) compose about 1% of the general population, appear to be more susceptible to idiopathic presenile cataract formation, and may be more prone to secondary cataract formation after a variety of lenticular insults. Dietary restriction of milk and milk products may prevent or delay cataract formation in these individuals. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/7352874/Presenile_cataract_formation_and_decreased_activity_of_galactosemic_enzymes_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/98/pg/269 DB - PRIME DP - Unbound Medicine ER -