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Effect of ascorbic acid on urine pH in patients with injured spinal cords.
Am J Hosp Pharm. 1980 Feb; 37(2):235-7.AJ

Abstract

The ability of ascorbic acid to lower urinary pH in patients with spinal cord injury and neurogenic bladder was studied. Ascorbic acid (1 g four times daily) or placebo was administered for five days in a double-blind, crossover study to 20 patients with spinal cord injury and neurogenic bladder. Urine pH was measured for two days before and during administration of placebo or ascorbic acid. The mean decrease in urinary pH with ascorbic acid was 0.58, but this reduction was not statistically or clinically significant. Only 7 of 20 patients showed a mean urine pH of 5.5 or less (acidic) during treatment with ascorbic acid. The study suggests that an ascorbic acid dosage of 1 g four times daily should not be used to maintain an acidic urinary pH for control of urinary tract infections in patients with spinal cord injuries.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

7361797

Citation

Hetey, S K., et al. "Effect of Ascorbic Acid On Urine pH in Patients With Injured Spinal Cords." American Journal of Hospital Pharmacy, vol. 37, no. 2, 1980, pp. 235-7.
Hetey SK, Kleinberg ML, Parker WD, et al. Effect of ascorbic acid on urine pH in patients with injured spinal cords. Am J Hosp Pharm. 1980;37(2):235-7.
Hetey, S. K., Kleinberg, M. L., Parker, W. D., & Johnson, E. W. (1980). Effect of ascorbic acid on urine pH in patients with injured spinal cords. American Journal of Hospital Pharmacy, 37(2), 235-7.
Hetey SK, et al. Effect of Ascorbic Acid On Urine pH in Patients With Injured Spinal Cords. Am J Hosp Pharm. 1980;37(2):235-7. PubMed PMID: 7361797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ascorbic acid on urine pH in patients with injured spinal cords. AU - Hetey,S K, AU - Kleinberg,M L, AU - Parker,W D, AU - Johnson,E W, PY - 1980/2/1/pubmed PY - 1980/2/1/medline PY - 1980/2/1/entrez SP - 235 EP - 7 JF - American journal of hospital pharmacy JO - Am J Hosp Pharm VL - 37 IS - 2 N2 - The ability of ascorbic acid to lower urinary pH in patients with spinal cord injury and neurogenic bladder was studied. Ascorbic acid (1 g four times daily) or placebo was administered for five days in a double-blind, crossover study to 20 patients with spinal cord injury and neurogenic bladder. Urine pH was measured for two days before and during administration of placebo or ascorbic acid. The mean decrease in urinary pH with ascorbic acid was 0.58, but this reduction was not statistically or clinically significant. Only 7 of 20 patients showed a mean urine pH of 5.5 or less (acidic) during treatment with ascorbic acid. The study suggests that an ascorbic acid dosage of 1 g four times daily should not be used to maintain an acidic urinary pH for control of urinary tract infections in patients with spinal cord injuries. SN - 0002-9289 UR - https://www.unboundmedicine.com/medline/citation/7361797/Effect_of_ascorbic_acid_on_urine_pH_in_patients_with_injured_spinal_cords_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -