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Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity.
N Engl J Med. 1980 May 01; 302(18):992-5.NEJM

Abstract

We studied 33 patients with sickle-cell anemia to examine the possible relation between the severity of their disease (frequency of microvascular occlusions) and the abnormal adherence of sickle erythrocytes to cultured human endothelium. Neither clinical severity nor erythrocyte adherence correlates significantly with red-cell indexes, hemoglobin concentration, percentage of irreversibly sickled red cells, level of fetal hemoglobin, or reticulocyte count. However, clinical severity and erythrocyte adherence are strongly correlated (rank correlation coefficient = +0.666; P less than 0.001). These findings are consistent with the hypothesis that abnormal interactions between erythrocytes and endothelium may be the initiating factor in the development of microvascular occlusions in sickle-cell anemia.

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Publisher Full Text

Authors

Hebbel RP
No affiliation info available
Boogaerts MA
No affiliation info available
Eaton JW
No affiliation info available
Steinberg MH
No affiliation info available

MeSH

AdolescentAnemia, Sickle CellCell AdhesionCulture TechniquesEndotheliumErythrocytes, AbnormalHumansMicrocirculation

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7366623

Clinical Trial Links

Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)

Citation

Hebbel, R P., et al. "Erythrocyte Adherence to Endothelium in Sickle-cell Anemia. a Possible Determinant of Disease Severity." The New England Journal of Medicine, vol. 302, no. 18, 1980, pp. 992-5.
Hebbel RP, Boogaerts MA, Eaton JW, et al. Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity. N Engl J Med. 1980;302(18):992-5.
Hebbel, R. P., Boogaerts, M. A., Eaton, J. W., & Steinberg, M. H. (1980). Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity. The New England Journal of Medicine, 302(18), 992-5.
Hebbel RP, et al. Erythrocyte Adherence to Endothelium in Sickle-cell Anemia. a Possible Determinant of Disease Severity. N Engl J Med. 1980 May 1;302(18):992-5. PubMed PMID: 7366623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity. AU - Hebbel,R P, AU - Boogaerts,M A, AU - Eaton,J W, AU - Steinberg,M H, PY - 1980/5/1/pubmed PY - 1980/5/1/medline PY - 1980/5/1/entrez SP - 992 EP - 5 JF - The New England journal of medicine JO - N Engl J Med VL - 302 IS - 18 N2 - We studied 33 patients with sickle-cell anemia to examine the possible relation between the severity of their disease (frequency of microvascular occlusions) and the abnormal adherence of sickle erythrocytes to cultured human endothelium. Neither clinical severity nor erythrocyte adherence correlates significantly with red-cell indexes, hemoglobin concentration, percentage of irreversibly sickled red cells, level of fetal hemoglobin, or reticulocyte count. However, clinical severity and erythrocyte adherence are strongly correlated (rank correlation coefficient = +0.666; P less than 0.001). These findings are consistent with the hypothesis that abnormal interactions between erythrocytes and endothelium may be the initiating factor in the development of microvascular occlusions in sickle-cell anemia. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/7366623/Erythrocyte_adherence_to_endothelium_in_sickle_cell_anemia__A_possible_determinant_of_disease_severity_ L2 - https://www.nejm.org/doi/10.1056/NEJM198005013021803?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -