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Plasma and urine changes after smoking different brands of cigarettes.
Clin Pharmacol Ther. 1980 May; 27(5):652-8.CP

Abstract

Concentrations of nicotine, cotinine, and carboxyhemoglobin (COHb) were measured in the plasma of subjects who smoked 1 cigarette of each of 10 different brands and then smoked 1 brand for 2 wk. There were higher COHb levels in smokers of low CO-yield cigarettes, whereas the rise in nicotine after 1 cigarette of each of the different brands was related to its nicotine content. Assay of urinary and plasma cotinine levels in smokers smoking brands with different nicotine content showed that smokers adjusted their smoking habits to maintain a constant level of cotinine. This self-titration of nicotine by the smoker may pose a health hazard even with relatively low nicotine cigarettes.

Links

Publisher Full Text

Authors

Hill P
No affiliation info available
Marquardt H
No affiliation info available

MeSH

Biological AvailabilityCarbon MonoxideCarboxyhemoglobinCoronary DiseaseCotinineHemoglobinsHumansNicotinePyrrolidinonesSmokingTime Factors

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7371362

Citation

Hill, P, and H Marquardt. "Plasma and Urine Changes After Smoking Different Brands of Cigarettes." Clinical Pharmacology and Therapeutics, vol. 27, no. 5, 1980, pp. 652-8.
Hill P, Marquardt H. Plasma and urine changes after smoking different brands of cigarettes. Clin Pharmacol Ther. 1980;27(5):652-8.
Hill, P., & Marquardt, H. (1980). Plasma and urine changes after smoking different brands of cigarettes. Clinical Pharmacology and Therapeutics, 27(5), 652-8.
Hill P, Marquardt H. Plasma and Urine Changes After Smoking Different Brands of Cigarettes. Clin Pharmacol Ther. 1980;27(5):652-8. PubMed PMID: 7371362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma and urine changes after smoking different brands of cigarettes. AU - Hill,P, AU - Marquardt,H, PY - 1980/5/1/pubmed PY - 1980/5/1/medline PY - 1980/5/1/entrez SP - 652 EP - 8 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 27 IS - 5 N2 - Concentrations of nicotine, cotinine, and carboxyhemoglobin (COHb) were measured in the plasma of subjects who smoked 1 cigarette of each of 10 different brands and then smoked 1 brand for 2 wk. There were higher COHb levels in smokers of low CO-yield cigarettes, whereas the rise in nicotine after 1 cigarette of each of the different brands was related to its nicotine content. Assay of urinary and plasma cotinine levels in smokers smoking brands with different nicotine content showed that smokers adjusted their smoking habits to maintain a constant level of cotinine. This self-titration of nicotine by the smoker may pose a health hazard even with relatively low nicotine cigarettes. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/7371362/Plasma_and_urine_changes_after_smoking_different_brands_of_cigarettes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1980&volume=27&issue=5&spage=652 DB - PRIME DP - Unbound Medicine ER -