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Complement consuming antibodies against a modified human serum protein in pigeon breeders' disease.
Immunobiology. 1980 Jan; 156(4-5):523-36.I

Abstract

The sera of patients with pigeon breeders' disease contain precipitating and human complement consuming antibodies against pigeon dropping antigens. Cessation of antigen exposure results in a decrease of precipitins below the level of detection in immunodiffusion. Complement consuming antibodies remain present, however, despite antigen avoidance. A close correlation is observed between human complement consumption tests with pigeon dropping antigens PDF1-A or pigeon cropmilk IgA and a modified human serum gamma-globulin. Isolation of this protein is readily achieved by its non-specific adsorption onto activated Sepharose 4B and subsequent elution with 1 M acetic acid. This modified protein may act as an autoantigen in pigeon breeders' disease, maintaining human complement consuming antibodies for years in subjects with no further bird antigen contact.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7372351

Citation

de Ridder, G, et al. "Complement Consuming Antibodies Against a Modified Human Serum Protein in Pigeon Breeders' Disease." Immunobiology, vol. 156, no. 4-5, 1980, pp. 523-36.
de Ridder G, van Dijk AG, Berrens L. Complement consuming antibodies against a modified human serum protein in pigeon breeders' disease. Immunobiology. 1980;156(4-5):523-36.
de Ridder, G., van Dijk, A. G., & Berrens, L. (1980). Complement consuming antibodies against a modified human serum protein in pigeon breeders' disease. Immunobiology, 156(4-5), 523-36.
de Ridder G, van Dijk AG, Berrens L. Complement Consuming Antibodies Against a Modified Human Serum Protein in Pigeon Breeders' Disease. Immunobiology. 1980;156(4-5):523-36. PubMed PMID: 7372351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complement consuming antibodies against a modified human serum protein in pigeon breeders' disease. AU - de Ridder,G, AU - van Dijk,A G, AU - Berrens,L, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 523 EP - 36 JF - Immunobiology JO - Immunobiology VL - 156 IS - 4-5 N2 - The sera of patients with pigeon breeders' disease contain precipitating and human complement consuming antibodies against pigeon dropping antigens. Cessation of antigen exposure results in a decrease of precipitins below the level of detection in immunodiffusion. Complement consuming antibodies remain present, however, despite antigen avoidance. A close correlation is observed between human complement consumption tests with pigeon dropping antigens PDF1-A or pigeon cropmilk IgA and a modified human serum gamma-globulin. Isolation of this protein is readily achieved by its non-specific adsorption onto activated Sepharose 4B and subsequent elution with 1 M acetic acid. This modified protein may act as an autoantigen in pigeon breeders' disease, maintaining human complement consuming antibodies for years in subjects with no further bird antigen contact. SN - 0171-2985 UR - https://www.unboundmedicine.com/medline/citation/7372351/Complement_consuming_antibodies_against_a_modified_human_serum_protein_in_pigeon_breeders'_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0171-2985(80)80085-4 DB - PRIME DP - Unbound Medicine ER -