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Effects of dietary variation in linoleic acid content on the major urinary metabolites of the E prostaglandins (PGE-M) in infants.

Abstract

1. EFA deficiency is associated with the impairment of prostaglandin E synthesis, which is reflected by the decrease of the urinary excretion of PGE-M. 2. Excessive administration of Intralipid results in increase of the relative concentrations of linoleic acid content in plasma, RBC, and tissues with a concomitant decrease of its higher homologue, arachidonic acid. These changes are associated with diminished PGE-M excretion similar to that seen in EFA deficiency. Further investigation is needed into the pathophysiologic consequences of EFA deficiency and the excessive administration of linoleic acid since both are associated with altered prostaglandin biosynthesis and turnover in the new-born infant, particularly among those stressed low birth weight infants whose nutritional status and management are an indication for these modes of therapy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7377030

Citation

Friedman, Z, et al. "Effects of Dietary Variation in Linoleic Acid Content On the Major Urinary Metabolites of the E Prostaglandins (PGE-M) in Infants." Advances in Prostaglandin and Thromboxane Research, vol. 8, 1980, pp. 1799-805.
Friedman Z, Seyberth H, Frölich J, et al. Effects of dietary variation in linoleic acid content on the major urinary metabolites of the E prostaglandins (PGE-M) in infants. Adv Prostaglandin Thromboxane Res. 1980;8:1799-805.
Friedman, Z., Seyberth, H., Frölich, J., & Oates, J. (1980). Effects of dietary variation in linoleic acid content on the major urinary metabolites of the E prostaglandins (PGE-M) in infants. Advances in Prostaglandin and Thromboxane Research, 8, 1799-805.
Friedman Z, et al. Effects of Dietary Variation in Linoleic Acid Content On the Major Urinary Metabolites of the E Prostaglandins (PGE-M) in Infants. Adv Prostaglandin Thromboxane Res. 1980;8:1799-805. PubMed PMID: 7377030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary variation in linoleic acid content on the major urinary metabolites of the E prostaglandins (PGE-M) in infants. AU - Friedman,Z, AU - Seyberth,H, AU - Frölich,J, AU - Oates,J, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 1799 EP - 805 JF - Advances in prostaglandin and thromboxane research JO - Adv Prostaglandin Thromboxane Res VL - 8 N2 - 1. EFA deficiency is associated with the impairment of prostaglandin E synthesis, which is reflected by the decrease of the urinary excretion of PGE-M. 2. Excessive administration of Intralipid results in increase of the relative concentrations of linoleic acid content in plasma, RBC, and tissues with a concomitant decrease of its higher homologue, arachidonic acid. These changes are associated with diminished PGE-M excretion similar to that seen in EFA deficiency. Further investigation is needed into the pathophysiologic consequences of EFA deficiency and the excessive administration of linoleic acid since both are associated with altered prostaglandin biosynthesis and turnover in the new-born infant, particularly among those stressed low birth weight infants whose nutritional status and management are an indication for these modes of therapy. SN - 0361-5952 UR - https://www.unboundmedicine.com/medline/citation/7377030/Effects_of_dietary_variation_in_linoleic_acid_content_on_the_major_urinary_metabolites_of_the_E_prostaglandins__PGE_M__in_infants_ DB - PRIME DP - Unbound Medicine ER -