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Fibrin degradation products and impedance plethysmography. Measurements in the diagnosis of acute deep vein thrombosis.
Arch Intern Med. 1980 Jul; 140(7):903-6.AI

Abstract

Measurement of fibrin degradation products (FDP) was evaluated in 152 consecutive patients referred because diagnosis of deep vein thrombosis (DVT) was suspected. All patients underwent impedance plethysmography (IPG), and venograms were obtained in 59. Sensitivity and specificity of FDP measurement, using venography as the standard, was 88% and 66%, respectively. Sensitivity and specificity of IPG was 77% and 79%, respectively. Specificity of the two tests combined, when both yielded abnormal results, was 93%. Patients were classified as (1) normal, (2) abnormal, or (3) equivocal on the basis of IPG. A significant difference in mean FDP concentration was found between groups 1 and 2 and groups 2 and 3. An overall correlation was found between degree of abnormality on IPG and FDP concentration. A quantitative determination of FDP is a practical and reliable screening test for DVT and, when used in conjunction with IPG, improves both sensitivity and specificity of the latter.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7387297

Citation

Foti, M E., and V Gurewich. "Fibrin Degradation Products and Impedance Plethysmography. Measurements in the Diagnosis of Acute Deep Vein Thrombosis." Archives of Internal Medicine, vol. 140, no. 7, 1980, pp. 903-6.
Foti ME, Gurewich V. Fibrin degradation products and impedance plethysmography. Measurements in the diagnosis of acute deep vein thrombosis. Arch Intern Med. 1980;140(7):903-6.
Foti, M. E., & Gurewich, V. (1980). Fibrin degradation products and impedance plethysmography. Measurements in the diagnosis of acute deep vein thrombosis. Archives of Internal Medicine, 140(7), 903-6.
Foti ME, Gurewich V. Fibrin Degradation Products and Impedance Plethysmography. Measurements in the Diagnosis of Acute Deep Vein Thrombosis. Arch Intern Med. 1980;140(7):903-6. PubMed PMID: 7387297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrin degradation products and impedance plethysmography. Measurements in the diagnosis of acute deep vein thrombosis. AU - Foti,M E, AU - Gurewich,V, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 903 EP - 6 JF - Archives of internal medicine JO - Arch Intern Med VL - 140 IS - 7 N2 - Measurement of fibrin degradation products (FDP) was evaluated in 152 consecutive patients referred because diagnosis of deep vein thrombosis (DVT) was suspected. All patients underwent impedance plethysmography (IPG), and venograms were obtained in 59. Sensitivity and specificity of FDP measurement, using venography as the standard, was 88% and 66%, respectively. Sensitivity and specificity of IPG was 77% and 79%, respectively. Specificity of the two tests combined, when both yielded abnormal results, was 93%. Patients were classified as (1) normal, (2) abnormal, or (3) equivocal on the basis of IPG. A significant difference in mean FDP concentration was found between groups 1 and 2 and groups 2 and 3. An overall correlation was found between degree of abnormality on IPG and FDP concentration. A quantitative determination of FDP is a practical and reliable screening test for DVT and, when used in conjunction with IPG, improves both sensitivity and specificity of the latter. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/7387297/Fibrin_degradation_products_and_impedance_plethysmography__Measurements_in_the_diagnosis_of_acute_deep_vein_thrombosis_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/140/pg/903 DB - PRIME DP - Unbound Medicine ER -