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Characterization of mutagenic principles and carcinogenicity of dill weed and seeds.
J Pharmacobiodyn. 1980 May; 3(5):236-44.JP

Abstract

Among the various kinds of spices tested, the aqueous extracts of dill weed from Anethum graveolens L. and dill seeds from A. sowa D.C. (Umbelliferae), exhibited a mutagenicity to Salmonella typhimurium, strains TA98 and TA100. The aqueous methanol extracts were fractionated by the mutation assay using the strain TA98 with S-9 Mix. Isorhamnetin 3-sulfate (persicarin) and quercetin 3-sulfate were characterized as the mutagenic principles. Carcinogenicity was not observed for dill weed and seeds when the diets containing these in 33% were administered for 450 and 410 days, respectively, to the inbred strain ACI rats.

Authors

Fukuoka M
No affiliation info available
Yoshihira K
No affiliation info available
Natori S
No affiliation info available
Sakamoto K
No affiliation info available
Iwahara S
No affiliation info available
Hosaka S
No affiliation info available
Hirono I
No affiliation info available

MeSH

AnimalsCarcinogensCondimentsFemaleFlavonoidsHydrolysisMaleMutagenicity TestsMutagensQuercetinRatsSeeds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7411385

Citation

Fukuoka, M, et al. "Characterization of Mutagenic Principles and Carcinogenicity of Dill Weed and Seeds." Journal of Pharmacobio-dynamics, vol. 3, no. 5, 1980, pp. 236-44.
Fukuoka M, Yoshihira K, Natori S, et al. Characterization of mutagenic principles and carcinogenicity of dill weed and seeds. J Pharmacobiodyn. 1980;3(5):236-44.
Fukuoka, M., Yoshihira, K., Natori, S., Sakamoto, K., Iwahara, S., Hosaka, S., & Hirono, I. (1980). Characterization of mutagenic principles and carcinogenicity of dill weed and seeds. Journal of Pharmacobio-dynamics, 3(5), 236-44.
Fukuoka M, et al. Characterization of Mutagenic Principles and Carcinogenicity of Dill Weed and Seeds. J Pharmacobiodyn. 1980;3(5):236-44. PubMed PMID: 7411385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of mutagenic principles and carcinogenicity of dill weed and seeds. AU - Fukuoka,M, AU - Yoshihira,K, AU - Natori,S, AU - Sakamoto,K, AU - Iwahara,S, AU - Hosaka,S, AU - Hirono,I, PY - 1980/5/1/pubmed PY - 1980/5/1/medline PY - 1980/5/1/entrez SP - 236 EP - 44 JF - Journal of pharmacobio-dynamics JO - J Pharmacobiodyn VL - 3 IS - 5 N2 - Among the various kinds of spices tested, the aqueous extracts of dill weed from Anethum graveolens L. and dill seeds from A. sowa D.C. (Umbelliferae), exhibited a mutagenicity to Salmonella typhimurium, strains TA98 and TA100. The aqueous methanol extracts were fractionated by the mutation assay using the strain TA98 with S-9 Mix. Isorhamnetin 3-sulfate (persicarin) and quercetin 3-sulfate were characterized as the mutagenic principles. Carcinogenicity was not observed for dill weed and seeds when the diets containing these in 33% were administered for 450 and 410 days, respectively, to the inbred strain ACI rats. SN - 0386-846X UR - https://www.unboundmedicine.com/medline/citation/7411385/Characterization_of_mutagenic_principles_and_carcinogenicity_of_dill_weed_and_seeds_ DB - PRIME DP - Unbound Medicine ER -