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Characteristics that predict risk of breast cancer before and after the menopause.

Abstract

In a case-control study of 1868 breast cancer patients and 3391 control patients we searched for characteristics that predicted risk of breast cancer diagnosed before and after menopause. Common to increased risk of this disease in both periods of womanhood were: early menarche and late menopause; delayed marriage and first childbirth; more nulliparity or reduced gravidity and parity; reduced frequency of abortions; shorter overall child-bearing interval; more advanced education, higher socioeconomic status, and more contraceptive usage; and familial tendencies toward the disease. Breast cancer patients diagnosed before menopause were leaner than controls at age 20 and at time of diagnosis, but breast cancer risk in the postmenopausal period was related to increased weight-for-height at diagnosis and greater weight-for-height at diagnosis and greater weight gain since age 20. Postmenopausal breast cancer patients had a longer interval between first and second childbirths. Frequency and duration of the gravid state, inversely related to breast cancer risk, were largely dependent on contraceptive practices rather than unexplained infertility per se. Whether the breast cancer reaches diagnosis before or after menopause, the bulk of evidence examined here supports the view that it has a common cause and is subject to modifying influences over the long period of cancer latency.

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  • Publisher Full Text
  • Authors

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    Source

    American journal of epidemiology 112:2 1980 Aug pg 258-68

    MeSH

    Abortion, Spontaneous
    Adolescent
    Adult
    Body Weight
    Breast Neoplasms
    California
    Contraceptives, Oral
    Female
    Humans
    Marriage
    Menarche
    Menopause
    Menstruation Disturbances
    Middle Aged
    Pregnancy
    Social Class

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7416152

    Citation

    Paffenbarger, R S., et al. "Characteristics That Predict Risk of Breast Cancer Before and After the Menopause." American Journal of Epidemiology, vol. 112, no. 2, 1980, pp. 258-68.
    Paffenbarger RS, Kampert JB, Chang HG. Characteristics that predict risk of breast cancer before and after the menopause. Am J Epidemiol. 1980;112(2):258-68.
    Paffenbarger, R. S., Kampert, J. B., & Chang, H. G. (1980). Characteristics that predict risk of breast cancer before and after the menopause. American Journal of Epidemiology, 112(2), pp. 258-68.
    Paffenbarger RS, Kampert JB, Chang HG. Characteristics That Predict Risk of Breast Cancer Before and After the Menopause. Am J Epidemiol. 1980;112(2):258-68. PubMed PMID: 7416152.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Characteristics that predict risk of breast cancer before and after the menopause. AU - Paffenbarger,R S,Jr AU - Kampert,J B, AU - Chang,H G, PY - 1980/8/1/pubmed PY - 2001/3/28/medline PY - 1980/8/1/entrez KW - Age Factors KW - Americas KW - Birth Intervals KW - Breast Cancer--etiology KW - California KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Contraceptive Usage KW - Cultural Background KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Educational Status KW - Ethnic Groups KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Marriage Age KW - Maternal Age KW - Menarche KW - Menopause KW - Menstruation KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Parental Age KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Pregnancy KW - Reproduction KW - Research Methodology KW - Socioeconomic Status KW - Studies KW - United States SP - 258 EP - 68 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 112 IS - 2 N2 - In a case-control study of 1868 breast cancer patients and 3391 control patients we searched for characteristics that predicted risk of breast cancer diagnosed before and after menopause. Common to increased risk of this disease in both periods of womanhood were: early menarche and late menopause; delayed marriage and first childbirth; more nulliparity or reduced gravidity and parity; reduced frequency of abortions; shorter overall child-bearing interval; more advanced education, higher socioeconomic status, and more contraceptive usage; and familial tendencies toward the disease. Breast cancer patients diagnosed before menopause were leaner than controls at age 20 and at time of diagnosis, but breast cancer risk in the postmenopausal period was related to increased weight-for-height at diagnosis and greater weight-for-height at diagnosis and greater weight gain since age 20. Postmenopausal breast cancer patients had a longer interval between first and second childbirths. Frequency and duration of the gravid state, inversely related to breast cancer risk, were largely dependent on contraceptive practices rather than unexplained infertility per se. Whether the breast cancer reaches diagnosis before or after menopause, the bulk of evidence examined here supports the view that it has a common cause and is subject to modifying influences over the long period of cancer latency. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/7416152/Characteristics_that_predict_risk_of_breast_cancer_before_and_after_the_menopause_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a112992 DB - PRIME DP - Unbound Medicine ER -