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Lymphomas associated with a tolerant lymphocytic choriomeningitis virus infection in mice.
Lab Anim. 1980 Apr; 14(2):117-21.LA

Abstract

On each of 2 occasions when a tolerant lymphocytic choriomeningitis (LCM) virus infection was introduced experimentally by a natural route into breeding stock of the Pirbright P(SD) mouse strain, and a comparison made with genetically identical controls, where was in successive generations an overall 15-fold increase in the incidence of lymphomas. Most of these were recognized clinically after the age of 16 months. The same observation was made in mice of the P(H) strain from which the P(SD) strain had been surgically derived. The finding is interpreted as the activation of an endogenous viral oncogene by the LCM infection. It was concurrently observed that the incidence of mammary tumours in the P(H) strain mice before the age of 16 months was markedly lower in the animals infected with LCM.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7431820

Citation

Skinner, H H., et al. "Lymphomas Associated With a Tolerant Lymphocytic Choriomeningitis Virus Infection in Mice." Laboratory Animals, vol. 14, no. 2, 1980, pp. 117-21.
Skinner HH, Knight EH, Lancaster MC. Lymphomas associated with a tolerant lymphocytic choriomeningitis virus infection in mice. Lab Anim. 1980;14(2):117-21.
Skinner, H. H., Knight, E. H., & Lancaster, M. C. (1980). Lymphomas associated with a tolerant lymphocytic choriomeningitis virus infection in mice. Laboratory Animals, 14(2), 117-21.
Skinner HH, Knight EH, Lancaster MC. Lymphomas Associated With a Tolerant Lymphocytic Choriomeningitis Virus Infection in Mice. Lab Anim. 1980;14(2):117-21. PubMed PMID: 7431820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphomas associated with a tolerant lymphocytic choriomeningitis virus infection in mice. AU - Skinner,H H, AU - Knight,E H, AU - Lancaster,M C, PY - 1980/4/1/pubmed PY - 1980/4/1/medline PY - 1980/4/1/entrez SP - 117 EP - 21 JF - Laboratory animals JO - Lab Anim VL - 14 IS - 2 N2 - On each of 2 occasions when a tolerant lymphocytic choriomeningitis (LCM) virus infection was introduced experimentally by a natural route into breeding stock of the Pirbright P(SD) mouse strain, and a comparison made with genetically identical controls, where was in successive generations an overall 15-fold increase in the incidence of lymphomas. Most of these were recognized clinically after the age of 16 months. The same observation was made in mice of the P(H) strain from which the P(SD) strain had been surgically derived. The finding is interpreted as the activation of an endogenous viral oncogene by the LCM infection. It was concurrently observed that the incidence of mammary tumours in the P(H) strain mice before the age of 16 months was markedly lower in the animals infected with LCM. SN - 0023-6772 UR - https://www.unboundmedicine.com/medline/citation/7431820/Lymphomas_associated_with_a_tolerant_lymphocytic_choriomeningitis_virus_infection_in_mice_ L2 - https://journals.sagepub.com/doi/10.1258/002367780780942854?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -