Tags

Type your tag names separated by a space and hit enter

Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function.
Exp Brain Res. 1980; 40(4):457-63.EB

Abstract

The endocochlear potential and potassium concentrations in endolymph and perilymph were simultaneously measured in the basal turn of the guinea pig cochlea with double-barreled K+ selective electrodes. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier were calculated from the rate of change of endolymph K+ concentration relative to the K+ electrochemical potential difference recorded during permanent anoxia. When anoxia was induced in guinea pigs treated with kanamycin, the rate of decline of the electrochemical potential difference for K+ between the endolymph and perilymph was reduced when compared to normal guinea pigs. In guinea pigs exposed to broad band noise at 115 dBA for periods from 11-15 days, the rate of decline of the electrochemical potential difference for K+ across the endolymph-perilymph barrier was reduced but not to the extent found in guinea pigs treated with kanamycin. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier showed substantial decreases in noise exposed and kanamycin treated guinea pigs, as compared to normal guinea pigs. The magnitude of decrease of K+ permeability of the endolymph-perilymph barrier by noise or kanamycin was correlated with suppression of the maximum output of the cochlear microphonic.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7439285

Citation

Konishi, T, and A N. Salt. "Permeability to Potassium of the Endolymph-perilymph Barrier and Its Possible Relation to Hair Cell Function." Experimental Brain Research, vol. 40, no. 4, 1980, pp. 457-63.
Konishi T, Salt AN. Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function. Exp Brain Res. 1980;40(4):457-63.
Konishi, T., & Salt, A. N. (1980). Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function. Experimental Brain Research, 40(4), 457-63.
Konishi T, Salt AN. Permeability to Potassium of the Endolymph-perilymph Barrier and Its Possible Relation to Hair Cell Function. Exp Brain Res. 1980;40(4):457-63. PubMed PMID: 7439285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function. AU - Konishi,T, AU - Salt,A N, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 457 EP - 63 JF - Experimental brain research JO - Exp Brain Res VL - 40 IS - 4 N2 - The endocochlear potential and potassium concentrations in endolymph and perilymph were simultaneously measured in the basal turn of the guinea pig cochlea with double-barreled K+ selective electrodes. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier were calculated from the rate of change of endolymph K+ concentration relative to the K+ electrochemical potential difference recorded during permanent anoxia. When anoxia was induced in guinea pigs treated with kanamycin, the rate of decline of the electrochemical potential difference for K+ between the endolymph and perilymph was reduced when compared to normal guinea pigs. In guinea pigs exposed to broad band noise at 115 dBA for periods from 11-15 days, the rate of decline of the electrochemical potential difference for K+ across the endolymph-perilymph barrier was reduced but not to the extent found in guinea pigs treated with kanamycin. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier showed substantial decreases in noise exposed and kanamycin treated guinea pigs, as compared to normal guinea pigs. The magnitude of decrease of K+ permeability of the endolymph-perilymph barrier by noise or kanamycin was correlated with suppression of the maximum output of the cochlear microphonic. SN - 0014-4819 UR - https://www.unboundmedicine.com/medline/citation/7439285/Permeability_to_potassium_of_the_endolymph_perilymph_barrier_and_its_possible_relation_to_hair_cell_function_ L2 - https://medlineplus.gov/potassium.html DB - PRIME DP - Unbound Medicine ER -