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The relationship between zinc protoporphyrin (ZPP) and "free" erythrocyte protoporphyrin (FEP) in lead-exposed individuals.
Int Arch Occup Environ Health. 1980; 47(2):165-77.IA

Abstract

The relationship between zinc protoporphyrin (ZPP) and total erythrocyte protoporphyrin, measured as "free" erythrocyte protoporphyrin (FEP), was determined in 194 adult subjects with different occupational and non-occupational lead exposures. Furthermore, the ZPP-FEP comparison was considered with respect to the dose-effect relationship of ZPP and FEP with blood lead (PbB) for males and females, respectively. Bilirubin (Bil.) interferences in ZPP analysis were taken into account. A very close and highly significant relationship (r = 0.962, P < 0.001) was established between ZPP and FEP values. A significant correlation (P < 0.001) between log ZPP or log FEP and PbB (males r = 0.767 and 0.718; females r = 0.525 and 0.405) was also found. It was established, by both in vitro and in vivo studies, that Bil. interferes with the ZPP fluorescence readings; the relationship between "false" positive ZPP concentrations and Bil. concentrations (in vitro r = 0.987, in vivo r = 0.903) was highly significant (P < 0.001). A small but highly significant (r = 0.948, P < 0.001) influence of increased carboxyhemoglobin (COHb) concentrations on the decrease in hematofluorometer ZPP readings, due to inadequate oxygenation of the blood, was found. The results obtained confirm the usefullness of ZPP determinations using hematofluorometers for surveillance of increased lead absorption but stress that the interfering effect of Bil., and to a lesser extent of COHb, cannot be ignored.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7440002

Citation

Karacić, V, et al. "The Relationship Between Zinc Protoporphyrin (ZPP) and "free" Erythrocyte Protoporphyrin (FEP) in Lead-exposed Individuals." International Archives of Occupational and Environmental Health, vol. 47, no. 2, 1980, pp. 165-77.
Karacić V, Prpić-Majić D, Telisman S. The relationship between zinc protoporphyrin (ZPP) and "free" erythrocyte protoporphyrin (FEP) in lead-exposed individuals. Int Arch Occup Environ Health. 1980;47(2):165-77.
Karacić, V., Prpić-Majić, D., & Telisman, S. (1980). The relationship between zinc protoporphyrin (ZPP) and "free" erythrocyte protoporphyrin (FEP) in lead-exposed individuals. International Archives of Occupational and Environmental Health, 47(2), 165-77.
Karacić V, Prpić-Majić D, Telisman S. The Relationship Between Zinc Protoporphyrin (ZPP) and "free" Erythrocyte Protoporphyrin (FEP) in Lead-exposed Individuals. Int Arch Occup Environ Health. 1980;47(2):165-77. PubMed PMID: 7440002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between zinc protoporphyrin (ZPP) and "free" erythrocyte protoporphyrin (FEP) in lead-exposed individuals. AU - Karacić,V, AU - Prpić-Majić,D, AU - Telisman,S, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 165 EP - 77 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 47 IS - 2 N2 - The relationship between zinc protoporphyrin (ZPP) and total erythrocyte protoporphyrin, measured as "free" erythrocyte protoporphyrin (FEP), was determined in 194 adult subjects with different occupational and non-occupational lead exposures. Furthermore, the ZPP-FEP comparison was considered with respect to the dose-effect relationship of ZPP and FEP with blood lead (PbB) for males and females, respectively. Bilirubin (Bil.) interferences in ZPP analysis were taken into account. A very close and highly significant relationship (r = 0.962, P < 0.001) was established between ZPP and FEP values. A significant correlation (P < 0.001) between log ZPP or log FEP and PbB (males r = 0.767 and 0.718; females r = 0.525 and 0.405) was also found. It was established, by both in vitro and in vivo studies, that Bil. interferes with the ZPP fluorescence readings; the relationship between "false" positive ZPP concentrations and Bil. concentrations (in vitro r = 0.987, in vivo r = 0.903) was highly significant (P < 0.001). A small but highly significant (r = 0.948, P < 0.001) influence of increased carboxyhemoglobin (COHb) concentrations on the decrease in hematofluorometer ZPP readings, due to inadequate oxygenation of the blood, was found. The results obtained confirm the usefullness of ZPP determinations using hematofluorometers for surveillance of increased lead absorption but stress that the interfering effect of Bil., and to a lesser extent of COHb, cannot be ignored. SN - 0340-0131 UR - https://www.unboundmedicine.com/medline/citation/7440002/The_relationship_between_zinc_protoporphyrin__ZPP__and_"free"_erythrocyte_protoporphyrin__FEP__in_lead_exposed_individuals_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -