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Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaca mulatta).
Am J Pathol. 1980 Oct; 101(1):17-29.AJ

Abstract

The immunopathologic findings in the testes and kidneys of 25 long-term vasectomized monkeys and of 13 age-matched control animals were compared. Antisperm antibody was found in serum samples from 60% of vasectomized monkeys and in no samples from control animals. Orchitis, aspermatogenesis, or both, resembling allergic orchitis, was noted in 92% of vasectomized animals and in 23% of controls. Epididymitis and epididymal granuloma occurred exclusively in the vasectomized animals (52%). By immunofluorescence, granular deposits of IgA, IgG, and/or C3 in the basal lamina of the ductuli efferentes and the caput epididymidis were detected in 45% of the control monkeys. In vasectomized animals, the incidence of immune deposits increased to 91%, and the deposits became more widespread. Although both vasectomized and control animals had IgM, IgG, or both, in the glomerular mesangial region, C3 was found in vasectomized monkeys only (29%). The results of this study indicate that monocytic infiltrations with aspermatogenesis in association with immune deposits along the excurrent duct normally occur in subhuman primates, and that these changes increase in incidence after vasectomy. Although the testicular disease highly resembles allergic orchitis, an immunologic basis remains to be established.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7446699

Citation

Tung, K S., and N J. Alexander. "Monocytic Orchitis and Aspermatogenesis in Normal and Vasectomized Rhesus Macaques (Macaca Mulatta)." The American Journal of Pathology, vol. 101, no. 1, 1980, pp. 17-29.
Tung KS, Alexander NJ. Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaca mulatta). Am J Pathol. 1980;101(1):17-29.
Tung, K. S., & Alexander, N. J. (1980). Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaca mulatta). The American Journal of Pathology, 101(1), 17-29.
Tung KS, Alexander NJ. Monocytic Orchitis and Aspermatogenesis in Normal and Vasectomized Rhesus Macaques (Macaca Mulatta). Am J Pathol. 1980;101(1):17-29. PubMed PMID: 7446699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaca mulatta). AU - Tung,K S, AU - Alexander,N J, PY - 1980/10/1/pubmed PY - 1980/10/1/medline PY - 1980/10/1/entrez SP - 17 EP - 29 JF - The American journal of pathology JO - Am J Pathol VL - 101 IS - 1 N2 - The immunopathologic findings in the testes and kidneys of 25 long-term vasectomized monkeys and of 13 age-matched control animals were compared. Antisperm antibody was found in serum samples from 60% of vasectomized monkeys and in no samples from control animals. Orchitis, aspermatogenesis, or both, resembling allergic orchitis, was noted in 92% of vasectomized animals and in 23% of controls. Epididymitis and epididymal granuloma occurred exclusively in the vasectomized animals (52%). By immunofluorescence, granular deposits of IgA, IgG, and/or C3 in the basal lamina of the ductuli efferentes and the caput epididymidis were detected in 45% of the control monkeys. In vasectomized animals, the incidence of immune deposits increased to 91%, and the deposits became more widespread. Although both vasectomized and control animals had IgM, IgG, or both, in the glomerular mesangial region, C3 was found in vasectomized monkeys only (29%). The results of this study indicate that monocytic infiltrations with aspermatogenesis in association with immune deposits along the excurrent duct normally occur in subhuman primates, and that these changes increase in incidence after vasectomy. Although the testicular disease highly resembles allergic orchitis, an immunologic basis remains to be established. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/7446699/Monocytic_orchitis_and_aspermatogenesis_in_normal_and_vasectomized_rhesus_macaques__Macaca_mulatta__ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7446699/ DB - PRIME DP - Unbound Medicine ER -