TY - JOUR T1 - Replacement of venography in suspected venous thrombosis by impedance plethysmography and 125I-fibrinogen leg scanning: a less invasive approach. AU - Hull,R, AU - Hirsh,J, AU - Sackett,D L, AU - Taylor,D W, AU - Carter,C, AU - Turpie,A G, AU - Zielinsky,A, AU - Powers,P, AU - Gent,M, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 12 EP - 5 JF - Annals of internal medicine JO - Ann Intern Med VL - 94 IS - 1 N2 - Noninvasive diagnostic testing is gaining acceptance in the evaluation of patients with clinically suspected venous thrombosis. Although clinically useful, all these tests have limitations, and the safety of basing therapeutic decisions on their outcome has not been assessed. We have done a prospective study of 322 symptomatic patients to ascertain the safety of replacing venography with impedance plethysmography and leg scanning. To provide a diagnostic reference, we did venography in all patients but withheld anticoagulants if the noninvasive tests were negative irrespective of the results of venography. None of the 163 patients with negative noninvasive tests died or developed clinical pulmonary embolism during 3 months' follow-up, confirming the safety of this approach. In two, clinically evident postvenographic venous thrombosis developed, confirmed by repetition of these objective tests. Also, the positive predictive values indicate that therapeutic decisions can be based on a positive noninvasive outcome in patients without clinical disorders known to produce false-positive results. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/7447204/Replacement_of_venography_in_suspected_venous_thrombosis_by_impedance_plethysmography_and_125I_fibrinogen_leg_scanning:_a_less_invasive_approach_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-94-1-12?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -