Replacement of venography in suspected venous thrombosis by impedance plethysmography and 125I-fibrinogen leg scanning: a less invasive approach.Ann Intern Med. 1981 Jan; 94(1):12-5.AIM
Noninvasive diagnostic testing is gaining acceptance in the evaluation of patients with clinically suspected venous thrombosis. Although clinically useful, all these tests have limitations, and the safety of basing therapeutic decisions on their outcome has not been assessed. We have done a prospective study of 322 symptomatic patients to ascertain the safety of replacing venography with impedance plethysmography and leg scanning. To provide a diagnostic reference, we did venography in all patients but withheld anticoagulants if the noninvasive tests were negative irrespective of the results of venography. None of the 163 patients with negative noninvasive tests died or developed clinical pulmonary embolism during 3 months' follow-up, confirming the safety of this approach. In two, clinically evident postvenographic venous thrombosis developed, confirmed by repetition of these objective tests. Also, the positive predictive values indicate that therapeutic decisions can be based on a positive noninvasive outcome in patients without clinical disorders known to produce false-positive results.