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Necrobiotic xanthogranuloma with paraproteinemia.
J Am Acad Dermatol 1980; 3(3):257-70JA

Abstract

Eight patients had multiple xanthomatous plaques and subcutaneous nodules that had a predilection for the periorbital area, flexures, and trunk and that tended to ulcerate. Skin biopsy specimens showed a combination of xanthogranulomatous nodules with necrobiosis. All patients had an accompanying dysproteinemia, which was a monoclonal IgG paraprotein in six. Hyperlipidemia, low serum complement, and cryoglobulinemia were variable features. Five patients had leukopenia. Bone marrow examination showed myeloma in two patients, a lymphoproliferative process in one, and some atypical plasma cells in two. Cutaneous necrobiotic xanthogranuloma is a distinctive histologic pattern most frequently related to plasma cell dyscrasias, and it should be distinguished from normolipemic plane xanthoma and other necrobiotic granulomas.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7451693

Citation

Kossard, S, and R K. Winkelmann. "Necrobiotic Xanthogranuloma With Paraproteinemia." Journal of the American Academy of Dermatology, vol. 3, no. 3, 1980, pp. 257-70.
Kossard S, Winkelmann RK. Necrobiotic xanthogranuloma with paraproteinemia. J Am Acad Dermatol. 1980;3(3):257-70.
Kossard, S., & Winkelmann, R. K. (1980). Necrobiotic xanthogranuloma with paraproteinemia. Journal of the American Academy of Dermatology, 3(3), pp. 257-70.
Kossard S, Winkelmann RK. Necrobiotic Xanthogranuloma With Paraproteinemia. J Am Acad Dermatol. 1980;3(3):257-70. PubMed PMID: 7451693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiotic xanthogranuloma with paraproteinemia. AU - Kossard,S, AU - Winkelmann,R K, PY - 1980/9/1/pubmed PY - 1980/9/1/medline PY - 1980/9/1/entrez SP - 257 EP - 70 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 3 IS - 3 N2 - Eight patients had multiple xanthomatous plaques and subcutaneous nodules that had a predilection for the periorbital area, flexures, and trunk and that tended to ulcerate. Skin biopsy specimens showed a combination of xanthogranulomatous nodules with necrobiosis. All patients had an accompanying dysproteinemia, which was a monoclonal IgG paraprotein in six. Hyperlipidemia, low serum complement, and cryoglobulinemia were variable features. Five patients had leukopenia. Bone marrow examination showed myeloma in two patients, a lymphoproliferative process in one, and some atypical plasma cells in two. Cutaneous necrobiotic xanthogranuloma is a distinctive histologic pattern most frequently related to plasma cell dyscrasias, and it should be distinguished from normolipemic plane xanthoma and other necrobiotic granulomas. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/7451693/Necrobiotic_xanthogranuloma_with_paraproteinemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(80)80189-7 DB - PRIME DP - Unbound Medicine ER -