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Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.
Physiol Chem Phys. 1980; 12(4):299-305.PC

Abstract

Biscoclaurine-type alkaloids were examined for ability to act as membrane-stabilizing agents and to protect against lipid peroxidation and deterioration of biological membrane. The following results were obtained. Biscoclaurine-type alkaloids inhibit Fe2+-induced lipid peroxidation of biological membrane. Cepharanthine protects against decrease in membrane compartmentation due to Fe2+-induced lipid peroxidation. Peroxidation of membrane lipid causes decrease in membrane fluidity but cepharanthine protects against this decrease. These protective actions are structure specific. They are also biscoclaurine-type specific and do not apply to coclaurine-type alkaloids such as papaverine. Based on these findings, the biological action of the alkaloid is discussed relative to membrane-stabilizing action and protective action against leukopenia induced by X-ray irradiation or mitomycin treatment in cancer therapy.

Authors

Shiraishi N
No affiliation info available
Arima T
No affiliation info available
Aono K
No affiliation info available
Inouye B
No affiliation info available
Morimoto Y
No affiliation info available
Utsumi K
No affiliation info available

MeSH

AlkaloidsAnimalsBenzylisoquinolinesCell CompartmentationCell MembraneFerrous CompoundsLiposomesMembrane FluidityMembrane LipidsPeroxidesPotassiumRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7454854

Citation

Shiraishi, N, et al. "Inhibition By Biscoclaurine Alkaloid of Lipid Peroxidation in Biological Membranes." Physiological Chemistry and Physics, vol. 12, no. 4, 1980, pp. 299-305.
Shiraishi N, Arima T, Aono K, et al. Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes. Physiol Chem Phys. 1980;12(4):299-305.
Shiraishi, N., Arima, T., Aono, K., Inouye, B., Morimoto, Y., & Utsumi, K. (1980). Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes. Physiological Chemistry and Physics, 12(4), 299-305.
Shiraishi N, et al. Inhibition By Biscoclaurine Alkaloid of Lipid Peroxidation in Biological Membranes. Physiol Chem Phys. 1980;12(4):299-305. PubMed PMID: 7454854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes. AU - Shiraishi,N, AU - Arima,T, AU - Aono,K, AU - Inouye,B, AU - Morimoto,Y, AU - Utsumi,K, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 299 EP - 305 JF - Physiological chemistry and physics JO - Physiol Chem Phys VL - 12 IS - 4 N2 - Biscoclaurine-type alkaloids were examined for ability to act as membrane-stabilizing agents and to protect against lipid peroxidation and deterioration of biological membrane. The following results were obtained. Biscoclaurine-type alkaloids inhibit Fe2+-induced lipid peroxidation of biological membrane. Cepharanthine protects against decrease in membrane compartmentation due to Fe2+-induced lipid peroxidation. Peroxidation of membrane lipid causes decrease in membrane fluidity but cepharanthine protects against this decrease. These protective actions are structure specific. They are also biscoclaurine-type specific and do not apply to coclaurine-type alkaloids such as papaverine. Based on these findings, the biological action of the alkaloid is discussed relative to membrane-stabilizing action and protective action against leukopenia induced by X-ray irradiation or mitomycin treatment in cancer therapy. SN - 0031-9325 UR - https://www.unboundmedicine.com/medline/citation/7454854/Inhibition_by_biscoclaurine_alkaloid_of_lipid_peroxidation_in_biological_membranes_ DB - PRIME DP - Unbound Medicine ER -