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Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer.
Acta Med Acad Sci Hung. 1980; 37(1):59-65.AM

Abstract

Synthetic salmon calcitonin infused intravenously in a pharmacological dose of 2 MRCU/kg/hour resulted in an abrupt and profound inhibition of basal and pentagastrin and calcium induced gastric acid secretion in patients with duodenal ulcer. The inhibition in the sixth 15-minute period of the intravenous infusion of calcitonin amounted to 98.7% (basal acid secretion), 51.8% (pentagastrin-stimulated acid secretion) and 80.9% (calcium-induced acid secretion). There were no significant alterations in the serum calcium and gastrin levels during the intravenous infusion of calcitonin. The slight decrease in serum gastrin concentration in the first 30 minutes of calcitonin infusion cannot explain the strong inhibition of gastric acid secretion produced by calcitonin. It is assumed that calcitonin inhibits directly the parietal cells.

Authors

Kisfalvi I
No affiliation info available
Földvári P
No affiliation info available
Szücs K
No affiliation info available

MeSH

AdultCalcitoninCalciumDuodenal UlcerGastric AcidGastric MucosaGastrinsHumansMaleMiddle AgedPentagastrin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7457018

Citation

Kisfalvi, I, et al. "Effect of Calcitonin On Basal and Pentagastrin- and Calcium-stimulated Gastric Acid Secretion in Patients With Duodenal Ulcer." Acta Medica Academiae Scientiarum Hungaricae, vol. 37, no. 1, 1980, pp. 59-65.
Kisfalvi I, Földvári P, Szücs K. Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer. Acta Med Acad Sci Hung. 1980;37(1):59-65.
Kisfalvi, I., Földvári, P., & Szücs, K. (1980). Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer. Acta Medica Academiae Scientiarum Hungaricae, 37(1), 59-65.
Kisfalvi I, Földvári P, Szücs K. Effect of Calcitonin On Basal and Pentagastrin- and Calcium-stimulated Gastric Acid Secretion in Patients With Duodenal Ulcer. Acta Med Acad Sci Hung. 1980;37(1):59-65. PubMed PMID: 7457018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer. AU - Kisfalvi,I, AU - Földvári,P, AU - Szücs,K, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 59 EP - 65 JF - Acta medica Academiae Scientiarum Hungaricae JO - Acta Med Acad Sci Hung VL - 37 IS - 1 N2 - Synthetic salmon calcitonin infused intravenously in a pharmacological dose of 2 MRCU/kg/hour resulted in an abrupt and profound inhibition of basal and pentagastrin and calcium induced gastric acid secretion in patients with duodenal ulcer. The inhibition in the sixth 15-minute period of the intravenous infusion of calcitonin amounted to 98.7% (basal acid secretion), 51.8% (pentagastrin-stimulated acid secretion) and 80.9% (calcium-induced acid secretion). There were no significant alterations in the serum calcium and gastrin levels during the intravenous infusion of calcitonin. The slight decrease in serum gastrin concentration in the first 30 minutes of calcitonin infusion cannot explain the strong inhibition of gastric acid secretion produced by calcitonin. It is assumed that calcitonin inhibits directly the parietal cells. SN - 0001-5989 UR - https://www.unboundmedicine.com/medline/citation/7457018/Effect_of_calcitonin_on_basal_and_pentagastrin__and_calcium_stimulated_gastric_acid_secretion_in_patients_with_duodenal_ulcer_ DB - PRIME DP - Unbound Medicine ER -