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Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations.
Am Ind Hyg Assoc J. 1980 Nov; 41(11):836-42.AI

Abstract

The fibrogenic potentials of coal and copper slags used as substitutes for silica sand in abrasive blasting operations were assessed in rats. The test animals were given a single pulmonary intralobar instillation of 20 mg of test material and were sacrificed 10 months after dosing. Pulmonary fibrosis was seen in the coal slag-treated rats while no fibrosis was seen in the copper slag-treated animals. Granulomas were seen in the lungs from all treatment groups. The results of the study emphasize the need for bioassay of silica sand replacements for fibrogenic potential in spite of the low free silica contents of these materials.

Authors

Mackay GR
No affiliation info available
Stettler LE
No affiliation info available
Kommineni C
No affiliation info available
Donaldson HM
No affiliation info available

MeSH

AnimalsCoalCopperDustGranulomaLung DiseasesMalePulmonary FibrosisRats

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7457375

Citation

Mackay, G R., et al. "Fibrogenic Potential of Slags Used as Substitutes for Sand in Abrasive Blasting Operations." American Industrial Hygiene Association Journal, vol. 41, no. 11, 1980, pp. 836-42.
Mackay GR, Stettler LE, Kommineni C, et al. Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations. Am Ind Hyg Assoc J. 1980;41(11):836-42.
Mackay, G. R., Stettler, L. E., Kommineni, C., & Donaldson, H. M. (1980). Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations. American Industrial Hygiene Association Journal, 41(11), 836-42.
Mackay GR, et al. Fibrogenic Potential of Slags Used as Substitutes for Sand in Abrasive Blasting Operations. Am Ind Hyg Assoc J. 1980;41(11):836-42. PubMed PMID: 7457375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations. AU - Mackay,G R, AU - Stettler,L E, AU - Kommineni,C, AU - Donaldson,H M, PY - 1980/11/1/pubmed PY - 1980/11/1/medline PY - 1980/11/1/entrez SP - 836 EP - 42 JF - American Industrial Hygiene Association journal JO - Am Ind Hyg Assoc J VL - 41 IS - 11 N2 - The fibrogenic potentials of coal and copper slags used as substitutes for silica sand in abrasive blasting operations were assessed in rats. The test animals were given a single pulmonary intralobar instillation of 20 mg of test material and were sacrificed 10 months after dosing. Pulmonary fibrosis was seen in the coal slag-treated rats while no fibrosis was seen in the copper slag-treated animals. Granulomas were seen in the lungs from all treatment groups. The results of the study emphasize the need for bioassay of silica sand replacements for fibrogenic potential in spite of the low free silica contents of these materials. SN - 0002-8894 UR - https://www.unboundmedicine.com/medline/citation/7457375/Fibrogenic_potential_of_slags_used_as_substitutes_for_sand_in_abrasive_blasting_operations_ L2 - https://medlineplus.gov/lungdiseases.html DB - PRIME DP - Unbound Medicine ER -