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Serological and virological studies on patients with dengue hemorrhagic fever (DHF) in Chanthaburi province, Thailand. I. Serological studies on paired sera from DHF patients by neutralization (N), hemagglutination inhibition (HI) and staining tests.
Biken J. 1980 Sep; 23(3):113-21.BJ

Abstract

Twenty paired sera were collected from DHF patients admitted to the provincial hospital of Chanthaburi, Thailand in 1978. They were tested by the N and HI tests and a newly developed staining test against all four serotypes of dengue (DEN) virus and Japanese encephalitis (JE) virus. Four patients were demonstrated to be cases of primary DEN infection and the other 16 to be cases of secondary DEN infection. The serotypes of recent DEN infections were easily determined by the N test in cases of primary infection, but were difficult to determine in cases of secondary infection because of the strong cross reactions among DEN serotypes. These cross reactions seemed to be due to subgroup-specific antibody, which reacts with all 4 serotypes of DEN virus in the N test. However, acute phase sera from some patients with the secondary type of antibody response reacted monospecifically in the N test, indicating the serotype of the primarily infecting viruses.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7458894

Citation

Okuno, Y, et al. "Serological and Virological Studies On Patients With Dengue Hemorrhagic Fever (DHF) in Chanthaburi Province, Thailand. I. Serological Studies On Paired Sera From DHF Patients By Neutralization (N), Hemagglutination Inhibition (HI) and Staining Tests." Biken Journal, vol. 23, no. 3, 1980, pp. 113-21.
Okuno Y, Fukunaga T, Srisupaluck S, et al. Serological and virological studies on patients with dengue hemorrhagic fever (DHF) in Chanthaburi province, Thailand. I. Serological studies on paired sera from DHF patients by neutralization (N), hemagglutination inhibition (HI) and staining tests. Biken J. 1980;23(3):113-21.
Okuno, Y., Fukunaga, T., Srisupaluck, S., Kasemsarn, P., Dharakul, C., & Sangkawibha, N. (1980). Serological and virological studies on patients with dengue hemorrhagic fever (DHF) in Chanthaburi province, Thailand. I. Serological studies on paired sera from DHF patients by neutralization (N), hemagglutination inhibition (HI) and staining tests. Biken Journal, 23(3), 113-21.
Okuno Y, et al. Serological and Virological Studies On Patients With Dengue Hemorrhagic Fever (DHF) in Chanthaburi Province, Thailand. I. Serological Studies On Paired Sera From DHF Patients By Neutralization (N), Hemagglutination Inhibition (HI) and Staining Tests. Biken J. 1980;23(3):113-21. PubMed PMID: 7458894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological and virological studies on patients with dengue hemorrhagic fever (DHF) in Chanthaburi province, Thailand. I. Serological studies on paired sera from DHF patients by neutralization (N), hemagglutination inhibition (HI) and staining tests. AU - Okuno,Y, AU - Fukunaga,T, AU - Srisupaluck,S, AU - Kasemsarn,P, AU - Dharakul,C, AU - Sangkawibha,N, PY - 1980/9/1/pubmed PY - 1980/9/1/medline PY - 1980/9/1/entrez SP - 113 EP - 21 JF - Biken journal JO - Biken J VL - 23 IS - 3 N2 - Twenty paired sera were collected from DHF patients admitted to the provincial hospital of Chanthaburi, Thailand in 1978. They were tested by the N and HI tests and a newly developed staining test against all four serotypes of dengue (DEN) virus and Japanese encephalitis (JE) virus. Four patients were demonstrated to be cases of primary DEN infection and the other 16 to be cases of secondary DEN infection. The serotypes of recent DEN infections were easily determined by the N test in cases of primary infection, but were difficult to determine in cases of secondary infection because of the strong cross reactions among DEN serotypes. These cross reactions seemed to be due to subgroup-specific antibody, which reacts with all 4 serotypes of DEN virus in the N test. However, acute phase sera from some patients with the secondary type of antibody response reacted monospecifically in the N test, indicating the serotype of the primarily infecting viruses. SN - 0006-2324 UR - https://www.unboundmedicine.com/medline/citation/7458894/Serological_and_virological_studies_on_patients_with_dengue_hemorrhagic_fever__DHF__in_Chanthaburi_province_Thailand__I__Serological_studies_on_paired_sera_from_DHF_patients_by_neutralization__N__hemagglutination_inhibition__HI__and_staining_tests_ L2 - http://www.diseaseinfosearch.org/result/2187 DB - PRIME DP - Unbound Medicine ER -