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Regional CNS levels of acetylcholine and choline during hypoglycemic stupor and recovery.
J Neurochem. 1981 Jan; 36(1):321-4.JN

Abstract

During insulin stupor in mice, acetylcholine levels in cerebral cortex, cerebellum, brainstem, striatum, and hippocampus were unchanged from control values despite brain glucose concentrations 3-10% of normal, whereas choline levels rose 2.4-3.6-fold in all five CNS regions. Brain acetylcholine and choline levels did not change during recovery following glucose injection. The data suggest that, in hypoglycemic stupor, (1) overall rates of acetylcholine synthesis and degradation remain balanced within each of the CNS regions studied; (2) the biochemical mechanism that elevates brain choline levels is unlikely to be related only to cholinergic synaptic processes; and (3) brain choline levels need not rise for stupor to occur.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7463059

Citation

Gorell, J M., et al. "Regional CNS Levels of Acetylcholine and Choline During Hypoglycemic Stupor and Recovery." Journal of Neurochemistry, vol. 36, no. 1, 1981, pp. 321-4.
Gorell JM, Navarro CP, Schwendner SP. Regional CNS levels of acetylcholine and choline during hypoglycemic stupor and recovery. J Neurochem. 1981;36(1):321-4.
Gorell, J. M., Navarro, C. P., & Schwendner, S. P. (1981). Regional CNS levels of acetylcholine and choline during hypoglycemic stupor and recovery. Journal of Neurochemistry, 36(1), 321-4.
Gorell JM, Navarro CP, Schwendner SP. Regional CNS Levels of Acetylcholine and Choline During Hypoglycemic Stupor and Recovery. J Neurochem. 1981;36(1):321-4. PubMed PMID: 7463059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional CNS levels of acetylcholine and choline during hypoglycemic stupor and recovery. AU - Gorell,J M, AU - Navarro,C P, AU - Schwendner,S P, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 321 EP - 4 JF - Journal of neurochemistry JO - J Neurochem VL - 36 IS - 1 N2 - During insulin stupor in mice, acetylcholine levels in cerebral cortex, cerebellum, brainstem, striatum, and hippocampus were unchanged from control values despite brain glucose concentrations 3-10% of normal, whereas choline levels rose 2.4-3.6-fold in all five CNS regions. Brain acetylcholine and choline levels did not change during recovery following glucose injection. The data suggest that, in hypoglycemic stupor, (1) overall rates of acetylcholine synthesis and degradation remain balanced within each of the CNS regions studied; (2) the biochemical mechanism that elevates brain choline levels is unlikely to be related only to cholinergic synaptic processes; and (3) brain choline levels need not rise for stupor to occur. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/7463059/Regional_CNS_levels_of_acetylcholine_and_choline_during_hypoglycemic_stupor_and_recovery_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=1981&volume=36&issue=1&spage=321 DB - PRIME DP - Unbound Medicine ER -