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Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias.
Scand J Haematol. 1980 Sep; 25(3):231-6.SJ

Abstract

Deoxyuridine (dU) suppression test and granulocyte macrophage colony forming unit (CFU-GM) assay were performed, along with morphological analysis, vitamin B12 and folate assays, in 22 cases of macrocytic anaemia corresponding to various types of idiopathic dysmyelopoietic syndromes. The dU suppressive effect was found to be normal in 19 cases, and slightly subnormal in 3 cases. The parallel study of the in vitro bone marrow growth showed, except in cases of primary acquired sideroblastic anaemia, a reduced number of colonies associated with a relative increase of the cluster formation. Consequently, these two parallel functional studies can support a formal diagnosis of potentially preleukaemic myelodysplasia, whatever may be the morphological pattern and even in cases of marked macrocytic anaemias and secondary epiphenomenal folate or vitamin B12 deficiency.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7466311

Citation

Garand, R, et al. "Deoxyuridine-suppression Test and Bone Marrow Culture for the Diagnosis of Macrocytic Refractory Anaemias." Scandinavian Journal of Haematology, vol. 25, no. 3, 1980, pp. 231-6.
Garand R, Zittoun J, Marquet J, et al. Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias. Scand J Haematol. 1980;25(3):231-6.
Garand, R., Zittoun, J., Marquet, J., Mouraud, E., Grolleau, J. Y., Le Mevel, A., & Zittoun, R. (1980). Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias. Scandinavian Journal of Haematology, 25(3), 231-6.
Garand R, et al. Deoxyuridine-suppression Test and Bone Marrow Culture for the Diagnosis of Macrocytic Refractory Anaemias. Scand J Haematol. 1980;25(3):231-6. PubMed PMID: 7466311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias. AU - Garand,R, AU - Zittoun,J, AU - Marquet,J, AU - Mouraud,E, AU - Grolleau,J Y, AU - Le Mevel,A, AU - Zittoun,R, PY - 1980/9/1/pubmed PY - 1980/9/1/medline PY - 1980/9/1/entrez SP - 231 EP - 6 JF - Scandinavian journal of haematology JO - Scand J Haematol VL - 25 IS - 3 N2 - Deoxyuridine (dU) suppression test and granulocyte macrophage colony forming unit (CFU-GM) assay were performed, along with morphological analysis, vitamin B12 and folate assays, in 22 cases of macrocytic anaemia corresponding to various types of idiopathic dysmyelopoietic syndromes. The dU suppressive effect was found to be normal in 19 cases, and slightly subnormal in 3 cases. The parallel study of the in vitro bone marrow growth showed, except in cases of primary acquired sideroblastic anaemia, a reduced number of colonies associated with a relative increase of the cluster formation. Consequently, these two parallel functional studies can support a formal diagnosis of potentially preleukaemic myelodysplasia, whatever may be the morphological pattern and even in cases of marked macrocytic anaemias and secondary epiphenomenal folate or vitamin B12 deficiency. SN - 0036-553X UR - https://www.unboundmedicine.com/medline/citation/7466311/Deoxyuridine_suppression_test_and_bone_marrow_culture_for_the_diagnosis_of_macrocytic_refractory_anaemias_ DB - PRIME DP - Unbound Medicine ER -